HCSGD entry for FOXL2


1. General information

Official gene symbolFOXL2
Entrez ID668
Gene full nameforkhead box L2
Other gene symbolsBPES BPES1 PFRK PINTO POF3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0001541Ovarian follicle developmentIMP ISSbiological_process
GO:0002074Extraocular skeletal muscle developmentIMPbiological_process
GO:0003677DNA bindingIDA TASmolecular_function
GO:0003690Double-stranded DNA bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityISS NASmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0006309Apoptotic DNA fragmentationIMPbiological_process
GO:0006366Transcription from RNA polymerase II promoterIBAbiological_process
GO:0007389Pattern specification processIBAbiological_process
GO:0008134Transcription factor bindingIBAmolecular_function
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0019101Female somatic sex determinationIBAbiological_process
GO:0030154Cell differentiationNASbiological_process
GO:0030331Estrogen receptor bindingIBAmolecular_function
GO:0031624Ubiquitin conjugating enzyme bindingIPImolecular_function
GO:0042703MenstruationIMPbiological_process
GO:0043028Cysteine-type endopeptidase regulator activity involved in apoptotic processIMPmolecular_function
GO:0043065Positive regulation of apoptotic processIGI IMPbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0048048Embryonic eye morphogenesisIBAbiological_process
GO:0051090Regulation of sequence-specific DNA binding transcription factor activityIBAbiological_process
GO:0060014Granulosa cell differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06367407010.79094911670.54414454551.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4296752302
GSE13712_SHEARDown-0.0625220338
GSE13712_STATICDown-0.3163007805
GSE19018Up0.0971115969
GSE19899_A1Up0.1072144402
GSE19899_A2Up1.6245206378
PubMed_21979375_A1Up0.5873297128
PubMed_21979375_A2Up1.9523287512
GSE35957Up0.0562997205
GSE36640Up0.1610504726
GSE54402Up0.2909617771
GSE9593Up0.0811681418
GSE43922Up0.2543612606
GSE24585Up0.0188302195
GSE37065Down-0.0224950363
GSE28863_A1Down-0.1672281018
GSE28863_A2Down-0.2652138124
GSE28863_A3Down-0.4843471443
GSE28863_A4Down-0.0999871735
GSE48662Down-0.0078840402

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.