HCSGD entry for SP100

1. General information

Official gene symbolSP100
Entrez ID6672
Gene full nameSP100 nuclear antigen
Other gene symbolslysp100b
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000723Telomere maintenanceIMPbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0003714Transcription corepressor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDA IMPcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIDAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010596Negative regulation of endothelial cell migrationIMPbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016605PML bodyIDAcellular_component
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019900Kinase bindingIPImolecular_function
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0030870Mre11 complexIDAcellular_component
GO:0032526Response to retinoic acidIDAbiological_process
GO:0032897Negative regulation of viral transcriptionIDAbiological_process
GO:0034097Response to cytokineIDAbiological_process
GO:0034340Response to type I interferonIDA IMPbiological_process
GO:0034341Response to interferon-gammaIDA IMPbiological_process
GO:0034399Nuclear peripheryIDAcellular_component
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043392Negative regulation of DNA bindingIDAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0045765Regulation of angiogenesisIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0046826Negative regulation of protein export from nucleusIMPbiological_process
GO:0048384Retinoic acid receptor signaling pathwayICbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0051271Negative regulation of cellular component movementIMPbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayIC TASbiological_process
GO:0060337Type I interferon signaling pathwayICbiological_process
GO:0070087Chromo shadow domain bindingIPImolecular_function
GO:1902041Regulation of extrinsic apoptotic signaling pathway via death domain receptorsIMPbiological_process
GO:1902044Regulation of Fas signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00295736100.99362151890.14616097561.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1497768656
GSE13712_SHEARUp1.1748388636
GSE13712_STATICUp0.9924719162
GSE19018Up0.6503481733
GSE19899_A1Up0.4394238668
GSE19899_A2Up0.7980434611
PubMed_21979375_A1Up0.5491281480
PubMed_21979375_A2Up0.4756034141
GSE35957Down-0.4271602058
GSE36640Up0.6110527559
GSE54402Up0.9827876581
GSE9593Up0.0706056166
GSE43922Up0.3035311400
GSE24585Up0.4246830901
GSE37065Up0.5823330688
GSE28863_A1Up0.1418533453
GSE28863_A2Up0.3975164811
GSE28863_A3Down-0.2662028227
GSE28863_A4Down-0.0467815125
GSE48662Down-0.1710632603

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT032264ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21198351PML is the organizer of the NBs that contains at least 2 permanent NB-associated proteins, the IFN-stimulated gene product Speckled protein of 100 kDa (Sp100) and death-associated dead protein (Daxx), as well as numerous other transient proteins recruited in these structures in response to different stimuli
12511612Cotransfection of cells with a plasmid expressing the CFP conjugate of Sp100 (another marker protein for the PML nuclear body) also showed colocalization of the yellow fluorescent protein (YFP)-SRC1 containing nuclear foci with the PML bodies in living cells
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