HCSGD entry for SOX10

1. General information

Official gene symbolSOX10
Entrez ID6663
Gene full nameSRY (sex determining region Y)-box 10
Other gene symbolsDOM PCWH WS2E WS4 WS4C
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001755Neural crest cell migrationIEAbiological_process
GO:0002052Positive regulation of neuroblast proliferationIEAbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEA ISScellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0007422Peripheral nervous system developmentIEAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0014015Positive regulation of gliogenesisIEAbiological_process
GO:0030318Melanocyte differentiationIEAbiological_process
GO:0031315Extrinsic component of mitochondrial outer membraneIEAcellular_component
GO:0042802Identical protein bindingIPImolecular_function
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0048469Cell maturationIEAbiological_process
GO:0048484Enteric nervous system developmentIEAbiological_process
GO:0048546Digestive tract morphogenesisIEAbiological_process
GO:0048589Developmental growthIEAbiological_process
GO:0048709Oligodendrocyte differentiationIEAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75477834810.77012492690.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1304390775
GSE13712_SHEARDown-0.0667897375
GSE13712_STATICDown-0.0796075365
GSE19018Down-0.0036931051
GSE19899_A1Down-0.0290365095
GSE19899_A2Up0.1899548220
PubMed_21979375_A1Down-0.1063781095
PubMed_21979375_A2Up0.0493333259
GSE35957Up0.2010382975
GSE36640Down-0.0292193274
GSE54402Up0.0114067513
GSE9593Up0.1478082673
GSE43922Up0.0641786694
GSE24585Down-0.1104717924
GSE37065Up0.0130141404
GSE28863_A1Down-0.1420901793
GSE28863_A2Down-0.0940177701
GSE28863_A3Up0.3602930090
GSE28863_A4Up0.0657246943
GSE48662Down-0.0143891063

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.