HCSGD entry for SOX9

1. General information

Official gene symbolSOX9
Entrez ID6662
Gene full nameSRY (sex determining region Y)-box 9
Other gene symbolsCMD1 CMPD1 SRA1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001046Core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001158Enhancer sequence-specific DNA bindingISSmolecular_function
GO:0001501Skeletal system developmentIMPbiological_process
GO:0001502Cartilage condensationISSbiological_process
GO:0001503OssificationIEAbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0001708Cell fate specificationISSbiological_process
GO:0001837Epithelial to mesenchymal transitionISSbiological_process
GO:0001894Tissue homeostasisISSbiological_process
GO:0001934Positive regulation of protein phosphorylationISSbiological_process
GO:0001942Hair follicle developmentISSbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationISSbiological_process
GO:0002683Negative regulation of immune system processISSbiological_process
GO:0003170Heart valve developmentISSbiological_process
GO:0003179Heart valve morphogenesisISSbiological_process
GO:0003188Heart valve formationIEAbiological_process
GO:0003203Endocardial cushion morphogenesisISSbiological_process
GO:0003413Chondrocyte differentiation involved in endochondral bone morphogenesisIMPbiological_process
GO:0003415Chondrocyte hypertrophyISSbiological_process
GO:0003682Chromatin bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IMPmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0004672Protein kinase activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006334Nucleosome assemblyIDAbiological_process
GO:0006338Chromatin remodelingIDAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006461Protein complex assemblyIDAbiological_process
GO:0007165Signal transductionISSbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayISSbiological_process
GO:0007283SpermatogenesisISSbiological_process
GO:0008013Beta-catenin bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIMPbiological_process
GO:0008584Male gonad developmentIEP IMPbiological_process
GO:0010564Regulation of cell cycle processIMPbiological_process
GO:0010634Positive regulation of epithelial cell migrationIMPbiological_process
GO:0014032Neural crest cell developmentIEAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingISSbiological_process
GO:0019100Male germ-line sex determinationISSbiological_process
GO:0019933CAMP-mediated signalingIDAbiological_process
GO:0030155Regulation of cell adhesionIEAbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0030279Negative regulation of ossificationISSbiological_process
GO:0030502Negative regulation of bone mineralizationIEAbiological_process
GO:0030850Prostate gland developmentIEPbiological_process
GO:0030858Positive regulation of epithelial cell differentiationISSbiological_process
GO:0030879Mammary gland developmentIEAbiological_process
GO:0030903Notochord developmentIEAbiological_process
GO:0030916Otic vesicle formationISSbiological_process
GO:0031018Endocrine pancreas developmentIEAbiological_process
GO:0032331Negative regulation of chondrocyte differentiationISSbiological_process
GO:0032332Positive regulation of chondrocyte differentiationIDA IMPbiological_process
GO:0034236Protein kinase A catalytic subunit bindingIPImolecular_function
GO:0035019Somatic stem cell maintenanceISSbiological_process
GO:0035326Enhancer bindingIDAmolecular_function
GO:0035622Intrahepatic bile duct developmentIEAbiological_process
GO:0042127Regulation of cell proliferationISSbiological_process
GO:0042981Regulation of apoptotic processISSbiological_process
GO:0043066Negative regulation of apoptotic processIMP ISSbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043425BHLH transcription factor bindingIEAmolecular_function
GO:0043491Protein kinase B signalingIEAbiological_process
GO:0045662Negative regulation of myoblast differentiationISSbiological_process
GO:0045732Positive regulation of protein catabolic processIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046533Negative regulation of photoreceptor cell differentiationISSbiological_process
GO:0048709Oligodendrocyte differentiationIEAbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIEP ISSbiological_process
GO:0050680Negative regulation of epithelial cell proliferationISSbiological_process
GO:0051216Cartilage developmentISSbiological_process
GO:0060008Sertoli cell differentiationISSbiological_process
GO:0060009Sertoli cell developmentIEAbiological_process
GO:0060018Astrocyte fate commitmentIEAbiological_process
GO:0060041Retina development in camera-type eyeISSbiological_process
GO:0060174Limb bud formationIEAbiological_process
GO:0060221Retinal rod cell differentiationISSbiological_process
GO:0060517Epithelial cell proliferation involved in prostatic bud elongationISSbiological_process
GO:0060729Intestinal epithelial structure maintenanceISSbiological_process
GO:0060784Regulation of cell proliferation involved in tissue homeostasisISSbiological_process
GO:0061036Positive regulation of cartilage developmentIDAbiological_process
GO:0061138Morphogenesis of a branching epitheliumISSbiological_process
GO:0070168Negative regulation of biomineral tissue developmentISSbiological_process
GO:0070371ERK1 and ERK2 cascadeISSbiological_process
GO:0071260Cellular response to mechanical stimulusISSbiological_process
GO:0071300Cellular response to retinoic acidIEPbiological_process
GO:0071347Cellular response to interleukin-1IEPbiological_process
GO:0071364Cellular response to epidermal growth factor stimulusISSbiological_process
GO:0071504Cellular response to heparinISSbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIDAbiological_process
GO:0072034Renal vesicle inductionISSbiological_process
GO:0072190Ureter urothelium developmentIEAbiological_process
GO:0072197Ureter morphogenesisIEAbiological_process
GO:0072289Metanephric nephron tubule formationISSbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayISSbiological_process
GO:0090103Cochlea morphogenesisISSbiological_process
GO:0090184Positive regulation of kidney developmentISSbiological_process
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisISSbiological_process
GO:2000020Positive regulation of male gonad developmentIDAbiological_process
GO:2000138Positive regulation of cell proliferation involved in heart morphogenesisIEAbiological_process
GO:2000741Positive regulation of mesenchymal stem cell differentiationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57442835760.06754315950.99999024730.4904285517

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5638223250
GSE13712_SHEARDown-0.0591561219
GSE13712_STATICDown-0.0893040723
GSE19018Down-0.3859342591
GSE19899_A1Down-0.0305733162
GSE19899_A2Up0.1748764206
PubMed_21979375_A1Down-1.3012273239
PubMed_21979375_A2Up0.0845537025
GSE35957Down-1.3539674696
GSE36640Down-0.0726930035
GSE54402Down-0.0506150891
GSE9593Down-0.4065764742
GSE43922Up0.0097318317
GSE24585Up0.3693481663
GSE37065Up0.1431922199
GSE28863_A1Up0.0431483397
GSE28863_A2Down-0.1461216131
GSE28863_A3Up0.5888926063
GSE28863_A4Down-0.1376950009
GSE48662Down-0.0887841817

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-199a-5pMIMAT0000231MIRT006193qRT-PCRFunctional MTI (Weak)22441842
hsa-let-7b-5pMIMAT0000063MIRT005049MicroarrayFunctional MTI (Weak)17699775
hsa-miR-101-3pMIMAT0000099MIRT007091Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23178713
hsa-miR-1MIMAT0000416MIRT007222Luciferase reporter assayFunctional MTI23352489
hsa-miR-335-5pMIMAT0000765MIRT017858MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26878385BACKGROUND: SOX2 and SOX9 are commonly overexpressed in glioblastoma, and regulate the activity of glioma stem cells (GSCs)
26878385METHODS: SOX2 and SOX9 levels were examined in human biopsies
26878385RESULTS: SOX2 and SOX9 expression correlates positively in glioma cells and glioblastoma biopsies
26878385Mechanistic investigations revealed that SOX2 acts upstream of SOX9
25826898Senescence marker (p16INK4a) and disc degeneration markers [A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS 5), Aggrecan, and Sry-related HMG box transcription factor 9 (Sox-9)] were determined in the NP specimens with immunohistochemistry and Western blot
25826898The protein expressions of Aggrecan and Sox-9 in the NP with grade IV degeneration were significantly lower than those in the NP with grade III degeneration (P < 0
23804221The CD73(+)CD39(+) cell subset displayed higher expression levels of Sox9 and Runx2 and a significantly greater chondro-osteogenic potency than the CD73(+)CD39(-) cell subset
23727861We show that ZBTB7A physically interacts with SOX9 and functionally antagonizes its transcriptional activity on key target genes such as MIA, which is involved in tumor cell invasion, and H19, a long noncoding RNA precursor for an RB-targeting microRNA
23106341More chondrocyte-like cells and higher proteoglycan deposition, Sox9 and collagen type II expression were observed in TDSCs (CI) pellets upon chondrogenic induction
23106341There was a higher protein expression of Sox9, but a lower mRNA expression of Col1a1, Scx, and Tnmd in TDSCs (CI) in a basal medium
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