HCSGD entry for SOX5

1. General information

Official gene symbolSOX5
Entrez ID6660
Gene full nameSRY (sex determining region Y)-box 5
Other gene symbolsL-SOX5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0021953Central nervous system neuron differentiationIEAbiological_process
GO:0032332Positive regulation of chondrocyte differentiationIDAbiological_process
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0045165Cell fate commitmentIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048709Oligodendrocyte differentiationIEAbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0060164Regulation of timing of neuron differentiationIEAbiological_process
GO:0061036Positive regulation of cartilage developmentIDAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIDAbiological_process
GO:2000741Positive regulation of mesenchymal stem cell differentiationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.71746010790.46159059690.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0527550180
GSE13712_SHEARDown-0.0819702065
GSE13712_STATICDown-0.0414861436
GSE19018Up0.0973214838
GSE19899_A1Down-0.1502612403
GSE19899_A2Down-0.0766717419
PubMed_21979375_A1Down-0.1158408662
PubMed_21979375_A2Up0.0403322817
GSE35957Down-0.1702227358
GSE36640Up0.3834890066
GSE54402Up0.3789759873
GSE9593Down-0.1769476508
GSE43922Down-0.0636583419
GSE24585Down-0.1465295622
GSE37065Up0.7221999078
GSE28863_A1Down-0.0296239971
GSE28863_A2Down-0.0467524167
GSE28863_A3Up0.1124324226
GSE28863_A4Down-0.0301531300
GSE48662Up0.0597536707

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT000960Western blot//Northern blot//qRT-PCR//Luciferase reporter assayFunctional MTI19013014
hsa-miR-21-5pMIMAT0000076MIRT000960MicroarrayFunctional MTI (Weak)18591254
hsa-miR-194-5pMIMAT0000460MIRT006327Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22396742
hsa-miR-335-5pMIMAT0000765MIRT016813MicroarrayFunctional MTI (Weak)18185580
hsa-miR-1MIMAT0000416MIRT023491MicroarrayFunctional MTI (Weak)18668037
hsa-miR-26b-5pMIMAT0000083MIRT028774MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-21-5pMIMAT00000761hsa-miR-2119013014
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19219070Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence
19219070SOX5 is a member of the high-mobility group superfamily of architectural non-histone proteins involved in gene regulation and maintenance of chromatin structure in a wide variety of developmental processes
19219070Sox5 was identified as a brain tumor locus in a retroviral insertional mutagenesis screen of platelet-derived growth factor B (PDGFB)-induced mouse gliomas
19219070Here we have investigated the role of Sox5 in PDGFB-induced gliomagenesis in mice
19219070We show that Sox5 can suppress PDGFB-induced glioma development predominantly upon Ink4a-loss
19219070In human glioma cell lines and tissues, we found very low levels of SOX5 compared with normal brain
19219070Overexpression of Sox5 in human glioma cells led to a reduction in clone formation and inhibition of proliferation
19219070Combined expression of Sox5 and PDGFB in primary brain cell cultures caused decreased proliferation and an increased number of senescent cells in the Ink4a-/- cells only
19219070Protein analyses showed a reduction in the amount and activation of Akt and increased levels of p27(Kip1) upon Sox5 expression that was dominant to PDGFB signaling and specific to Ink4a-/- cells
19219070Upon inhibition of p27(Kip1), the effects of Sox5 on proliferation and senescence could be reversed
19219070Our data suggest a novel pathway, where Sox5 may suppress the oncogenic effects of PDGFB signaling during glioma development by regulating p27(Kip1) in a p19(Arf)-dependent manner, leading to acute cellular senescence
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