HCSGD entry for BOK
1. General information
| Official gene symbol | BOK |
|---|---|
| Entrez ID | 666 |
| Gene full name | BCL2-related ovarian killer |
| Other gene symbols | BCL2L9 BOKL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | IBA | cellular_component |
| GO:0006915 | Apoptotic process | IDA | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0008283 | Cell proliferation | IEP | biological_process |
| GO:0008584 | Male gonad development | IEA | biological_process |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IBA | biological_process |
| GO:0031966 | Mitochondrial membrane | IDA | cellular_component |
| GO:0042803 | Protein homodimerization activity | IBA | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IBA | molecular_function |
| GO:0048709 | Oligodendrocyte differentiation | IEA | biological_process |
| GO:0051400 | BH domain binding | IEA | molecular_function |
| GO:0051402 | Neuron apoptotic process | IEA | biological_process |
| GO:0072332 | Intrinsic apoptotic signaling pathway by p53 class mediator | IMP | biological_process |
| GO:0097192 | Extrinsic apoptotic signaling pathway in absence of ligand | IBA | biological_process |
| GO:1900119 | Positive regulation of execution phase of apoptosis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3508766118 | 0.0380210744 | 0.9999902473 | 0.3673835169 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.4051745163 |
| GSE13712_SHEAR | Down | -0.2978017039 |
| GSE13712_STATIC | Up | 0.2415092751 |
| GSE19018 | Down | -0.1783074455 |
| GSE19899_A1 | Down | -0.3114594080 |
| GSE19899_A2 | Up | 0.3625603225 |
| PubMed_21979375_A1 | Up | 1.2663610885 |
| PubMed_21979375_A2 | Up | 2.0045254718 |
| GSE35957 | Down | -0.8368723973 |
| GSE36640 | Down | -0.4580330275 |
| GSE54402 | Up | 0.0767469612 |
| GSE9593 | Down | -0.0942576211 |
| GSE43922 | Up | 0.1743431984 |
| GSE24585 | Up | 0.0650241915 |
| GSE37065 | Down | -0.2900814006 |
| GSE28863_A1 | Down | -0.1031078033 |
| GSE28863_A2 | Down | -0.0537845373 |
| GSE28863_A3 | Down | -0.5526423859 |
| GSE28863_A4 | Down | -0.3762566535 |
| GSE48662 | Up | 0.1783596239 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-331-3p | MIMAT0000760 | MIRT043544 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22829758 | These include COL4A3, CFLAR, GULP1, PDCD1, CASP10, PAX3, BOK, HSPD1, PITX2, and PML |
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