HCSGD entry for SOX4

1. General information

Official gene symbolSOX4
Entrez ID6659
Gene full nameSRY (sex determining region Y)-box 4
Other gene symbolsEVI16
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000976Transcription regulatory region sequence-specific DNA bindingISSmolecular_function
GO:0001046Core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0001071Nucleic acid binding transcription factor activityIMPmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001105RNA polymerase II transcription coactivator activityISSmolecular_function
GO:0001501Skeletal system developmentISSbiological_process
GO:0001841Neural tube formationISSbiological_process
GO:0002328Pro-B cell differentiationISSbiological_process
GO:0003183Mitral valve morphogenesisISSbiological_process
GO:0003211Cardiac ventricle formationISSbiological_process
GO:0003215Cardiac right ventricle morphogenesisISSbiological_process
GO:0003289Atrial septum primum morphogenesisISSbiological_process
GO:0003357Noradrenergic neuron differentiationISSbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDA ISSbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestIMPbiological_process
GO:0007507Heart developmentISSbiological_process
GO:0008284Positive regulation of cell proliferationIMPbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0014009Glial cell proliferationISSbiological_process
GO:0021510Spinal cord developmentISSbiological_process
GO:0021522Spinal cord motor neuron differentiationISSbiological_process
GO:0021782Glial cell developmentISSbiological_process
GO:0030177Positive regulation of Wnt signaling pathwayISSbiological_process
GO:0030217T cell differentiationISSbiological_process
GO:0031018Endocrine pancreas developmentIEAbiological_process
GO:0031397Negative regulation of protein ubiquitinationIMPbiological_process
GO:0031647Regulation of protein stabilityIMPbiological_process
GO:0032024Positive regulation of insulin secretionISSbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0035910Ascending aorta morphogenesisISSbiological_process
GO:0042593Glucose homeostasisISSbiological_process
GO:0042769DNA damage response, detection of DNA damageIDAbiological_process
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0045727Positive regulation of translationIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0046826Negative regulation of protein export from nucleusIMPbiological_process
GO:0048485Sympathetic nervous system developmentISSbiological_process
GO:0050821Protein stabilizationIMPbiological_process
GO:0060070Canonical Wnt signaling pathwayISSbiological_process
GO:0060174Limb bud formationISSbiological_process
GO:0060412Ventricular septum morphogenesisISSbiological_process
GO:0060548Negative regulation of cell deathISSbiological_process
GO:0060563Neuroepithelial cell differentiationISSbiological_process
GO:0060993Kidney morphogenesisISSbiological_process
GO:0071333Cellular response to glucose stimulusISSbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayISSbiological_process
GO:2000761Positive regulation of N-terminal peptidyl-lysine acetylationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15643015080.03358311230.78544307220.3458298513

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5850526380
GSE13712_SHEARDown-0.4146643140
GSE13712_STATICDown-0.2700836253
GSE19018Down-0.5560995319
GSE19899_A1Up0.1841858363
GSE19899_A2Down-0.3065179702
PubMed_21979375_A1Down-0.0738396878
PubMed_21979375_A2Up0.6470372726
GSE35957Down-1.1456093346
GSE36640Up0.4200723553
GSE54402Up0.0617730155
GSE9593Down-1.1957302865
GSE43922Up0.3593560005
GSE24585Down-1.6176356482
GSE37065Up0.0490803742
GSE28863_A1Up0.1936732711
GSE28863_A2Up0.2418338998
GSE28863_A3Up0.5335671516
GSE28863_A4Down-0.1190963365
GSE48662Down-0.2387430015

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT002431Immunohistochemistry//Luciferase reporter assay//Microarray//Microarray;OtherFunctional MTI18185580
hsa-miR-129-5pMIMAT0000242MIRT004043In situ hybridization//Microarray//qRT-PCRFunctional MTI (Weak)19487295
hsa-miR-129-5pMIMAT0000242MIRT004043Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19887623
hsa-miR-191-5pMIMAT0000440MIRT004691Immunohistochemistry//Immunoprecipitaion//Luciferase reporter assay//Microarray//qRT-PCRFunctional MTI20924108
hsa-miR-129-2-3pMIMAT0004605MIRT006648Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19887623
hsa-miR-204-5pMIMAT0000265MIRT007100Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23204229
hsa-miR-138-5pMIMAT0000430MIRT007335Luciferase reporter assayFunctional MTI23389731
hsa-miR-151a-5pMIMAT0004697MIRT019525SequencingFunctional MTI (Weak)20371350
hsa-miR-340-5pMIMAT0004692MIRT019646SequencingFunctional MTI (Weak)20371350
hsa-miR-30b-5pMIMAT0000420MIRT023445SequencingFunctional MTI (Weak)20371350
hsa-miR-98-5pMIMAT0000096MIRT027786MicroarrayFunctional MTI (Weak)19088304
hsa-miR-30c-5pMIMAT0000244MIRT047893CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050802CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-204-5pMIMAT0000265NAhsa-miR-20420369013
hsa-miR-129-5pMIMAT00002421hsa-miR-129-5p{Western blot}{overexpression by miRNA precursor transfection}19887623
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27446439In addition, reverse transcription-quantitative polymerase chain reaction was used to demonstrate that gender determining region Y-box 4 (SOX4) is upregulated in ESCC, and that its expression is inversely correlated with senescence markers
27446439In addition, the knockdown of SOX4 expression by short hairpin RNA decreases ESCC cell proliferation and enhances doxorubicin-induced cell senescence
27446439These results reveal the presence of a senescent microenvironment in ESCC, and suggest an important antisenescence role of SOX4 in ESCC progression
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