HCSGD entry for SOS2
1. General information
| Official gene symbol | SOS2 |
|---|---|
| Entrez ID | 6655 |
| Gene full name | son of sevenless homolog 2 (Drosophila) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007264 | Small GTPase mediated signal transduction | IEA TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0051057 | Positive regulation of small GTPase mediated signal transduction | IEA | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6157053797 | 0.1833632195 | 0.9999902473 | 0.8299747721 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0477515005 |
| GSE13712_SHEAR | Up | 0.1618149545 |
| GSE13712_STATIC | Up | 0.0543512458 |
| GSE19018 | Up | 0.0842474174 |
| GSE19899_A1 | Down | -0.1325389081 |
| GSE19899_A2 | Down | -0.2418397119 |
| PubMed_21979375_A1 | Down | -0.4563388664 |
| PubMed_21979375_A2 | Down | -0.1336122518 |
| GSE35957 | Up | 0.3830191092 |
| GSE36640 | Down | -0.1618726408 |
| GSE54402 | Down | -0.0498700571 |
| GSE9593 | Up | 0.0415897207 |
| GSE43922 | Down | -0.0402923192 |
| GSE24585 | Up | 0.8473414545 |
| GSE37065 | Up | 0.2962262816 |
| GSE28863_A1 | Down | -0.1465861953 |
| GSE28863_A2 | Down | -0.2777344636 |
| GSE28863_A3 | Down | -0.8447883653 |
| GSE28863_A4 | Up | 0.0738545138 |
| GSE48662 | Down | -0.0899628617 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019010 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023126 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT046544 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
