HCSGD entry for SOS1

1. General information

Official gene symbolSOS1
Entrez ID6654
Gene full nameson of sevenless homolog 1 (Drosophila)
Other gene symbolsGF1 GGF1 GINGF HGF NS4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIEAmolecular_function
GO:0005088Ras guanyl-nucleotide exchange factor activityEXP IEA TASmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005100Rho GTPase activator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0007165Signal transductionNASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007264Small GTPase mediated signal transductionIEA TASbiological_process
GO:0007265Ras protein signal transductionIEA TASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0032318Regulation of Ras GTPase activityEXP TASbiological_process
GO:0032319Regulation of Rho GTPase activityTASbiological_process
GO:0032320Positive regulation of Ras GTPase activityTASbiological_process
GO:0032321Positive regulation of Rho GTPase activityTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043085Positive regulation of catalytic activityTASbiological_process
GO:0043087Regulation of GTPase activityEXP TASbiological_process
GO:0043547Positive regulation of GTPase activityTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045742Positive regulation of epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayIEA TASbiological_process
GO:0050790Regulation of catalytic activityTASbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0051057Positive regulation of small GTPase mediated signal transductionIEAbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15183803810.51845102770.77798890401.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0529536202
GSE13712_SHEARDown-0.1128137507
GSE13712_STATICDown-0.1996312395
GSE19018Up0.3635500477
GSE19899_A1Down-0.0420334192
GSE19899_A2Up0.0792969436
PubMed_21979375_A1Up0.1081440074
PubMed_21979375_A2Up0.5865741274
GSE35957Up0.2126749329
GSE36640Up0.3639499501
GSE54402Down-0.1662494046
GSE9593Up0.4596180944
GSE43922Down-0.0629475949
GSE24585Down-0.2625557664
GSE37065Up0.2016590233
GSE28863_A1Up0.5614226071
GSE28863_A2Up0.6642322042
GSE28863_A3Down-0.3984813181
GSE28863_A4Down-0.5208209268
GSE48662Up0.1368820419

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-23b-3pMIMAT0000418MIRT046240CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.