HCSGD entry for SOD1
1. General information
| Official gene symbol | SOD1 |
|---|---|
| Entrez ID | 6647 |
| Gene full name | superoxide dismutase 1, soluble |
| Other gene symbols | ALS ALS1 IPOA SOD hSod1 homodimer |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000187 | Activation of MAPK activity | ISS | biological_process |
| GO:0000303 | Response to superoxide | IDA | biological_process |
| GO:0001541 | Ovarian follicle development | ISS | biological_process |
| GO:0001819 | Positive regulation of cytokine production | IDA | biological_process |
| GO:0001890 | Placenta development | NAS | biological_process |
| GO:0001895 | Retina homeostasis | ISS | biological_process |
| GO:0001975 | Response to amphetamine | IEA | biological_process |
| GO:0002262 | Myeloid cell homeostasis | ISS | biological_process |
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0004784 | Superoxide dismutase activity | IDA IEA | molecular_function |
| GO:0005507 | Copper ion binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | NAS | cellular_component |
| GO:0005777 | Peroxisome | IDA ISS | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006302 | Double-strand break repair | ISS | biological_process |
| GO:0006309 | Apoptotic DNA fragmentation | ISS | biological_process |
| GO:0006749 | Glutathione metabolic process | ISS | biological_process |
| GO:0006801 | Superoxide metabolic process | IDA IEA ISS | biological_process |
| GO:0006879 | Cellular iron ion homeostasis | ISS | biological_process |
| GO:0007283 | Spermatogenesis | ISS | biological_process |
| GO:0007566 | Embryo implantation | ISS NAS | biological_process |
| GO:0007569 | Cell aging | IMP | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0007605 | Sensory perception of sound | ISS | biological_process |
| GO:0007626 | Locomotory behavior | ISS | biological_process |
| GO:0008089 | Anterograde axon cargo transport | ISS | biological_process |
| GO:0008090 | Retrograde axon cargo transport | ISS | biological_process |
| GO:0008217 | Regulation of blood pressure | ISS | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0009408 | Response to heat | ISS | biological_process |
| GO:0010033 | Response to organic substance | IDA | biological_process |
| GO:0019226 | Transmission of nerve impulse | ISS | biological_process |
| GO:0019430 | Removal of superoxide radicals | IBA ISS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030346 | Protein phosphatase 2B binding | IDA | molecular_function |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0031410 | Cytoplasmic vesicle | IDA | cellular_component |
| GO:0031667 | Response to nutrient levels | IEA | biological_process |
| GO:0032287 | Peripheral nervous system myelin maintenance | ISS | biological_process |
| GO:0032314 | Regulation of Rac GTPase activity | IDA | biological_process |
| GO:0032839 | Dendrite cytoplasm | IDA | cellular_component |
| GO:0032930 | Positive regulation of superoxide anion generation | IDA | biological_process |
| GO:0033081 | Regulation of T cell differentiation in thymus | NAS | biological_process |
| GO:0040014 | Regulation of multicellular organism growth | ISS | biological_process |
| GO:0042493 | Response to drug | ISS | biological_process |
| GO:0042542 | Response to hydrogen peroxide | ISS | biological_process |
| GO:0042554 | Superoxide anion generation | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | NAS | molecular_function |
| GO:0043025 | Neuronal cell body | IDA | cellular_component |
| GO:0043065 | Positive regulation of apoptotic process | IC | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | IDA | biological_process |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0043524 | Negative regulation of neuron apoptotic process | ISS | biological_process |
| GO:0045471 | Response to ethanol | ISS | biological_process |
| GO:0045541 | Negative regulation of cholesterol biosynthetic process | IDA | biological_process |
| GO:0045859 | Regulation of protein kinase activity | IDA | biological_process |
| GO:0046620 | Regulation of organ growth | NAS | biological_process |
| GO:0046688 | Response to copper ion | IEA | biological_process |
| GO:0046716 | Muscle cell cellular homeostasis | ISS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048365 | Rac GTPase binding | IDA | molecular_function |
| GO:0048538 | Thymus development | NAS | biological_process |
| GO:0048678 | Response to axon injury | ISS | biological_process |
| GO:0050665 | Hydrogen peroxide biosynthetic process | IDA ISS | biological_process |
| GO:0051087 | Chaperone binding | IPI | molecular_function |
| GO:0051881 | Regulation of mitochondrial membrane potential | IMP | biological_process |
| GO:0060047 | Heart contraction | IDA | biological_process |
| GO:0060052 | Neurofilament cytoskeleton organization | ISS | biological_process |
| GO:0060087 | Relaxation of vascular smooth muscle | ISS | biological_process |
| GO:0060088 | Auditory receptor cell stereocilium organization | ISS | biological_process |
| GO:0072593 | Reactive oxygen species metabolic process | IDA | biological_process |
| GO:1902177 | Positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8599586870 | 0.4562404354 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2266161302 |
| GSE13712_SHEAR | Up | 0.2060070490 |
| GSE13712_STATIC | Up | 0.0968535033 |
| GSE19018 | Up | 0.1671028104 |
| GSE19899_A1 | Down | -0.1783673251 |
| GSE19899_A2 | Down | -0.0953943007 |
| PubMed_21979375_A1 | Down | -0.0912624139 |
| PubMed_21979375_A2 | Down | -0.2096441662 |
| GSE35957 | Down | -0.1533521500 |
| GSE36640 | Up | 0.2757203683 |
| GSE54402 | Down | -0.0758785065 |
| GSE9593 | Up | 0.1390891418 |
| GSE43922 | Down | -0.2836611231 |
| GSE24585 | Down | -0.0740662024 |
| GSE37065 | Down | -0.0031555837 |
| GSE28863_A1 | Down | -0.1282544853 |
| GSE28863_A2 | Down | -0.0206590899 |
| GSE28863_A3 | Down | -0.2003161822 |
| GSE28863_A4 | Up | 0.0546309025 |
| GSE48662 | Down | -0.0796564495 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Compound | Target | Confidence score | Uniprot |
|---|---|---|---|
| CHEMBL272641 | CHEMBL2354 | 9 | P00441 |
| CHEMBL1672028 | CHEMBL2354 | 9 | P00441 |
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- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-377-3p | MIMAT0000730 | MIRT000992 | Luciferase reporter assay//Western blot | Functional MTI | 18716028 |
| hsa-miR-377-3p | MIMAT0000730 | MIRT000992 | Luciferase reporter assay// | Non-Functional MTI | 21203553 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043913 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048056 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 19 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26794818 | RESULTS: Our findings showed that SOD1 and CCS-1 were significantly down-regulated in pre-senescent cells while CCS-1 and PRDX6 were up-regulated in senescent cells (p<0 |
| 26696133 | SOD II levels increased gradually, whereas the SOD I and III levels were biphasic during the experimental periods after PPKO treatment |
| 25852816 | Using cultured fibroblasts with trisomy 21 (T21F), this study aimed to ascertain whether an imbalance exists in activities, mRNA, and protein expression of the antioxidant enzymes SOD1, SOD2, glutathione-peroxidase, and catalase during the cell replication process in vitro |
| 25852816 | T21F had high SOD1 expression and activity which led to an interenzymatic imbalance in the antioxidant defense system, accentuated with replicative senescence |
| 25839657 | Intracellular ROS levels were increased in hBM-MSCs; this was accompanied by a decrease in the expression of the antioxidant enzymes catalase and superoxide dismutase (SOD)1 and 2 and of phosphorylated forkhead box O1 (p-FOXO1) as well as an increase in the expression of p53 and p16, along with a reduction in differentiation potential |
| 25839657 | When the antioxidant ascorbic acid was used to eliminate excess ROS, the levels of antioxidant enzymes (catalase, SOD1 and 2, p-FOXO1, and p53) were partly restored |
| 25536029 | Chronic CI inhibition did not increase mitochondrial superoxide levels or cellular lipid peroxidation and was paralleled by a specific increase in SOD2/GR, whereas SOD1/CAT/Gpx1/Gpx2/Gpx5 levels remained unchanged |
| 25274775 | Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing |
| 23702294 | TRF1 is a homodimer with roles governing DNA architecture and negatively regulating telomere length |
| 23049256 | With an aim of reducing cellular senescence and oxidative stress in DPSCs, an intracellular delivery system for superoxide dismutase 1 (SOD1) was developed |
| 23049256 | We conjugated SOD1 with a cell-penetrating peptide known as low-molecular weight protamine (LMWP), and investigated the effect of LMWP-SOD1 conjugates on hydrogen peroxide-induced cellular senescence and osteoblastic differentiation |
| 21720015 | Mechanistically, we found that Rb1 could markedly increase intracellular superoxide dismutase (Cu/Zn SOD/SOD1) activity and decrease the malondialdehyde (MDA) level in H(2)O(2)-treated HUVECs, and suppress the generation of intracellular reactive oxygen species (ROS) |
| 21562236 | The expression of antioxidant defense genes, such as glutathione peroxidase-1, Cu/Zn superoxide dismutase (Sod1), paraoxonase enzymes (Pon1, Pon2, and Pon3), were significantly lower in the liver of HF/C pups than in C/C pups |
| 21538411 | The specific activities of zinc/copper (Zn/Cu)-superoxide dismutase (SOD-1) and manganese (Mn)-superoxide dismutase (SOD-2) were assayed in young passage 5 fibroblasts and in serially subcultured cells that were characterized as senescent at passages 15-35 |
| 21538411 | SOD-1 and SOD-2 activities did not significantly change in senescent and young cells cultured in either routine medium [minimum essential medium 1 (MEM1)], or in Zn, Cu and Mn supplemented medium (MEM2) containing normal human plasma levels of the cations |
| 21538411 | SOD-1 and SOD-2 activities, however, underwent parallel progressive significant activity increases in senescent passage 20 and 25 cells, which peaked in value in passage 30 and 35 cells subcultured in supplemented medium (MEM3) containing triple human plasma levels of the cations |
| 21538411 | We infer that it was only possible to significantly stimulate SOD-1 and SOD-2 activities in senescent MEM3 cultured cells enabling them to combat oxidative stress |
| 20812868 | S-Nitrosylation of protein-disulfide isomerase may also be associated with mutant Cu/Zn superoxide dismutase toxicity in amyotrophic lateral sclerosis |
| 20528770 | In contrast, up-regulation of Nuak2 (NUAK family, SNF1-like kinase 2) and down-regulation of Lonp2 (Lon peptidase 2), Foxo3a (forkhead box O3a), Sod1 (copper/zinc superoxide dismutase) and Sesn1 (sestrin 1) in the kidneys of recuperated offspring suggest that protein homoeostasis and resistance to oxidative stress are compromised, leading to accelerated cellular senescence in these shorter-lived mice |
| 16304208 | To begin to test this hypothesis, we compared the activities and steady-state mRNA and protein levels of the antioxidant enzymes copper zinc (CuZn) superoxide dismutase (CuZnSOD, SOD1), manganese (Mn) superoxide dismutase (MnSOD, SOD2), and glutathione peroxidase (GPx) and the levels of reduced and oxidized glutathione in Leydig cells isolated from the testes of young (4-month-old) and aged (20-month-old) Brown Norway rats |
| 14732290 | Our previous data highlight the importance of antioxidant enzymes, superoxide dismutase 1 (Sod1) and glutathione peroxidase 1 (Gpx1), in regulating this process |
| 14732290 | Previously, we demonstrated that a perturbation in the Sod1-to-Gpx1 ratio, as a consequence of Sod1 overexpression, leads to senescence-like changes |
| 14732290 | We proposed that this was mediated via the Sod1 dismutation product H2O2, because H2O2 induced similar changes in control cells |
| 14732290 | However, it has been suggested that H2O2 production, via Sod1 dismutation, is rate-limited by the availability of the substrate O2*-, and therefore age-related changes may occur as a result of other functions of Sod1 |
| 8824885 | Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide |
| 8824885 | In this study we investigate the effects of a perturbation in the ratio of Cu/Zn-superoxide dismutase activity (Sod1 dismutases |
| 8824885 | Furthermore, fibroblasts established from individuals with Down syndrome have an increase in the ratio of Sod1 to Gpx1 activity compared with corresponding controls and senesce earlier |
| 7492966 | Cu/Zn-superoxide dismutase and glutathione peroxidase during aging |
| 7492966 | This is based on our observation that an altered Cu/Zn-superoxide dismutase (Sod1)/(Gpx1 plus Cat) ratio exists in the brain of aging mice and that this correlates with increased lipid damage |
| 7492966 | Conversely, aging liver and kidney have an unaffected Sod1/(Gpx1 plus Cat) ratio and lipid damage is not increased with aging |
| 7492966 | We also examine the Sod1 to Gpx1 ratio in Down syndrome tissue and show that all organs have an altered ratio |
| 7492966 | Thus an altered Sod1/(Gpx1 plus Cat) ratio may also affect gene expression by altering the binding and/or availability of transcription factors to DNA |
| 8777435 | The susceptibility reduction may not be ascribed to extracellular Asc2P or DehAsc, which was removed by aspirating and/or rinsing upon irradiation after the intracellular channelyzer analysis and dead cell-specific DNA-intercalator ethidium homodimer/fluorometry, respectively |
| 8028395 | Intracellular Cu/Zn superoxide dismutase levels in T and non-T cells from normal aged subjects |
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