HCSGD entry for FSCN1
1. General information
| Official gene symbol | FSCN1 |
|---|---|
| Entrez ID | 6624 |
| Gene full name | fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) |
| Other gene symbols | FAN1 HSN SNL p55 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001725 | Stress fiber | IDA | cellular_component |
| GO:0003779 | Actin binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0008144 | Drug binding | IDA IEA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0015629 | Actin cytoskeleton | IDA | cellular_component |
| GO:0016477 | Cell migration | IEA IMP | biological_process |
| GO:0030036 | Actin cytoskeleton organization | IDA | biological_process |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0030175 | Filopodium | IDA IEA | cellular_component |
| GO:0030674 | Protein binding, bridging | IEA | molecular_function |
| GO:0048870 | Cell motility | IDA | biological_process |
| GO:0051015 | Actin filament binding | IDA IEA | molecular_function |
| GO:0051017 | Actin filament bundle assembly | IDA IEA | biological_process |
| GO:0071437 | Invadopodium | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9624169029 | 0.0091218951 | 0.9999902473 | 0.1887905882 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7039211555 |
| GSE13712_SHEAR | Up | 0.0165503190 |
| GSE13712_STATIC | Down | -0.3715409893 |
| GSE19018 | Down | -0.1624820162 |
| GSE19899_A1 | Down | -0.6833622803 |
| GSE19899_A2 | Down | -0.0736917682 |
| PubMed_21979375_A1 | Down | -0.9294031132 |
| PubMed_21979375_A2 | Down | -0.0719770210 |
| GSE35957 | Down | -0.4174583179 |
| GSE36640 | Down | -0.2892814230 |
| GSE54402 | Down | -0.3009413003 |
| GSE9593 | Down | -0.1686406989 |
| GSE43922 | Down | -0.1018564027 |
| GSE24585 | Up | 0.6165982195 |
| GSE37065 | Down | -0.6637464958 |
| GSE28863_A1 | Down | -0.4524077160 |
| GSE28863_A2 | Up | 0.0471765727 |
| GSE28863_A3 | Down | -0.3356450295 |
| GSE28863_A4 | Down | -0.3686301598 |
| GSE48662 | Up | 0.1676826038 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-133b | MIMAT0000770 | MIRT006554 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay | Functional MTI | 20198616 |
| hsa-miR-133b | MIMAT0000770 | MIRT006554 | Reporter assay;Western blot;qRT-PCR | Functional MTI | 21351259 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT003542 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20160723 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT003542 | Luciferase reporter assay | Functional MTI | 22292984 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT003542 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay;Western blot;qRT-PCR | Functional MTI | 21351259 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT003542 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay | Functional MTI | 20198616 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT003543 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20160723 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT003543 | Western blot | Non-Functional MTI | 21218087 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT003543 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay;Western blot;qRT-PCR;Microarray | Functional MTI | 21351259 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT003543 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay | Functional MTI | 20198616 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT003543 | Reporter assay | Functional MTI | 21258769 |
| hsa-miR-143-3p | MIMAT0000435 | MIRT005771 | Western blot | Non-Functional MTI | 21218087 |
| hsa-miR-143-3p | MIMAT0000435 | MIRT005771 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22457808 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028511 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046860 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050745 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-145-5p | MIMAT0000437 | 2 | hsa-miR-145 | {phenotypic sensor assay} | {overexpression by miRNA precursor transfection} | 20160723 | |
| hsa-miR-145-5p | MIMAT0000437 | 1 | hsa-miR-145 | {phenotypic sensor assay} | {overexpression by miRNA precursor transfection} | 20160723 | |
| hsa-miR-145-5p | MIMAT0000437 | 3 | hsa-miR-145 | {phenotypic sensor assay} | {overexpression by miRNA precursor transfection} | 20160723 | |
| hsa-miR-145-5p | MIMAT0000437 | 4 | hsa-miR-145 | {phenotypic sensor assay} | {overexpression by miRNA precursor transfection} | 20160723 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
