HCSGD entry for SMPD1

1. General information

Official gene symbolSMPD1
Entrez ID6609
Gene full namesphingomyelin phosphodiesterase 1, acid lysosomal
Other gene symbolsASM ASMASE NPD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004767Sphingomyelin phosphodiesterase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0006665Sphingolipid metabolic processTASbiological_process
GO:0006684Sphingomyelin metabolic processTASbiological_process
GO:0006685Sphingomyelin catabolic processIEAbiological_process
GO:0006687Glycosphingolipid metabolic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0016787Hydrolase activityIEAmolecular_function
GO:0016798Hydrolase activity, acting on glycosyl bondsIEAmolecular_function
GO:0023021Termination of signal transductionIMPbiological_process
GO:0035307Positive regulation of protein dephosphorylationIMPbiological_process
GO:0042220Response to cocaineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042599Lamellar bodyIEAcellular_component
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0043407Negative regulation of MAP kinase activityIMPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046513Ceramide biosynthetic processIEA IMPbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07703355500.46840514800.58609924861.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2356604728
GSE13712_SHEARDown-0.2207958302
GSE13712_STATICUp0.0641463297
GSE19018Up0.3553707844
GSE19899_A1Down-0.4697423800
GSE19899_A2Up0.4144198468
PubMed_21979375_A1Down-0.7100395322
PubMed_21979375_A2Up0.0960634212
GSE35957Up0.2849307108
GSE36640Up1.0194120180
GSE54402Down-0.2895559147
GSE9593Up0.7302172963
GSE43922Down-0.0487068910
GSE24585Up0.4177573346
GSE37065Up0.2197626235
GSE28863_A1Up0.0234582001
GSE28863_A2Up0.0026146457
GSE28863_A3Down-0.5731271872
GSE28863_A4Down-0.1660867035
GSE48662Up0.7754396979

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18203850We observed a clustering of membrane rafts shortly after exposure to GC; later, after 24 h, we observed an internalization, accompanied by an increased acid sphingomyelinase activity and accumulation of ceramide
Entries Per Page
Displaying Page of