HCSGD entry for SMN1
1. General information
| Official gene symbol | SMN1 |
|---|---|
| Entrez ID | 6606 |
| Gene full name | survival of motor neuron 1, telomeric |
| Other gene symbols | BCD541 GEMIN1 SMA SMA1 SMA2 SMA3 SMA4 SMA@ SMN SMNT T-BCD541 TDRD16A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000245 | Spliceosomal complex assembly | IMP NAS | biological_process |
| GO:0000387 | Spliceosomal snRNP assembly | IDA TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005681 | Spliceosomal complex | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006397 | MRNA processing | IEA | biological_process |
| GO:0007399 | Nervous system development | IEA | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0032797 | SMN complex | IDA | cellular_component |
| GO:0034660 | NcRNA metabolic process | TAS | biological_process |
| GO:0034719 | SMN-Sm protein complex | IDA | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0097504 | Gemini of coiled bodies | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9990816154 | 0.0233958854 | 0.9999902473 | 0.2948043083 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.5143052122 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-132-3p | MIMAT0000426 | MIRT021810 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028496 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029454 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23583398 | ATGL(-/-)mSMC showed spontaneous TG accumulation with lower mitogenic response and smooth muscle actin (SMA) expression compared to ATGL (+/+)mSMC |
| 23583398 | AdvATGL infection resulted in a reduction of TG accumulation with elevated mitogenic response and SMA expression, and decreased in senescent cell numbers in ATGL(-/-)mSMC |
| 21832251 | Inhibitors of NF-kappaB (pyrrolidine dithiocarbamate and isohelenin) and NF-kappaB p65 small interfering RNA (siRNA) suppressed indoxyl sulfate-induced senescence-associated beta-galactosidase activity and expression of p53, transforming growth factor (TGF)-beta1, and alpha-smoothe muscle actin (SMA) |
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