HCSGD entry for AACS
1. General information
| Official gene symbol | AACS |
|---|---|
| Entrez ID | 65985 |
| Gene full name | acetoacetyl-CoA synthetase |
| Other gene symbols | ACSF1 SUR-5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006631 | Fatty acid metabolic process | IEA | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0014074 | Response to purine-containing compound | IEA | biological_process |
| GO:0030729 | Acetoacetate-CoA ligase activity | IEA | molecular_function |
| GO:0032024 | Positive regulation of insulin secretion | IEA | biological_process |
| GO:0034201 | Response to oleic acid | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042594 | Response to starvation | IEA | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:0047760 | Butyrate-CoA ligase activity | IEA | molecular_function |
| GO:0050872 | White fat cell differentiation | IEA | biological_process |
| GO:0060612 | Adipose tissue development | IEA | biological_process |
| GO:0071333 | Cellular response to glucose stimulus | IEA | biological_process |
| GO:0071394 | Cellular response to testosterone stimulus | IEA | biological_process |
| GO:0071397 | Cellular response to cholesterol | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7446141712 | 0.1614499411 | 0.9999902473 | 0.7758352072 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1214292944 |
| GSE13712_SHEAR | Down | -0.3572970004 |
| GSE13712_STATIC | Down | -0.6302471949 |
| GSE19018 | Down | -0.1740945303 |
| GSE19899_A1 | Down | -0.0871398624 |
| GSE19899_A2 | Up | 0.4654129685 |
| PubMed_21979375_A1 | Up | 0.2974224809 |
| PubMed_21979375_A2 | Up | 0.8235886220 |
| GSE35957 | Down | -0.5783929860 |
| GSE36640 | Up | 0.0704932683 |
| GSE54402 | Up | 0.1321566512 |
| GSE9593 | Up | 0.0025624404 |
| GSE43922 | Up | 0.0926870203 |
| GSE24585 | Up | 0.0183502182 |
| GSE37065 | Down | -0.2507930126 |
| GSE28863_A1 | Down | -0.0029958596 |
| GSE28863_A2 | Down | -0.0863610305 |
| GSE28863_A3 | Down | -0.3453735963 |
| GSE28863_A4 | Up | 0.1173861944 |
| GSE48662 | Down | -0.2513946379 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT003093 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19296470 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037034 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-191-5p | MIMAT0000440 | MIRT045810 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
