HCSGD entry for SMARCA4

1. General information

Official gene symbolSMARCA4
Entrez ID6597
Gene full nameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Other gene symbolsBAF190 BAF190A BRG1 MRD16 RTPS2 SNF2 SNF2L4 SNF2LB SWI2 hSNF2b
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000792HeterochromatinIEAcellular_component
GO:0000902Cell morphogenesisIEAbiological_process
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIEAmolecular_function
GO:0001105RNA polymerase II transcription coactivator activityIDAmolecular_function
GO:0001570VasculogenesisIEAbiological_process
GO:0001832Blastocyst growthIEAbiological_process
GO:0001835Blastocyst hatchingIEAbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0002039P53 bindingIPImolecular_function
GO:0003407Neural retina developmentIEPbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003713Transcription coactivator activityIMP NASmolecular_function
GO:0003714Transcription corepressor activityIDAmolecular_function
GO:0004386Helicase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005719Nuclear euchromatinIEAcellular_component
GO:0005726Perichromatin fibrilsIEAcellular_component
GO:0006200ATP catabolic processIGIbiological_process
GO:0006337Nucleosome disassemblyIDAbiological_process
GO:0006338Chromatin remodelingIC IDAbiological_process
GO:0006346Methylation-dependent chromatin silencingIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterNASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0007070Negative regulation of transcription from RNA polymerase II promoter during mitosisTASbiological_process
GO:0007403Glial cell fate determinationIEAbiological_process
GO:0008094DNA-dependent ATPase activityIGImolecular_function
GO:0010424DNA methylation on cytosine within a CG sequenceIEAbiological_process
GO:0016514SWI/SNF complexIDAcellular_component
GO:0019827Stem cell maintenanceIEAbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0030216Keratinocyte differentiationIEAbiological_process
GO:0030308Negative regulation of cell growthIMPbiological_process
GO:0030900Forebrain developmentIEAbiological_process
GO:0030902Hindbrain developmentIEAbiological_process
GO:0030957Tat protein bindingIPImolecular_function
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035887Aortic smooth muscle cell differentiationIEAbiological_process
GO:0043388Positive regulation of DNA bindingIEAbiological_process
GO:0043923Positive regulation by host of viral transcriptionIMPbiological_process
GO:0043966Histone H3 acetylationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IGIbiological_process
GO:0047485Protein N-terminus bindingIPImolecular_function
GO:0048562Embryonic organ morphogenesisIEAbiological_process
GO:0048730Epidermis morphogenesisIEAbiological_process
GO:0050681Androgen receptor bindingIPImolecular_function
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0060318Definitive erythrocyte differentiationIEAbiological_process
GO:0060347Heart trabecula formationIEAbiological_process
GO:0060766Negative regulation of androgen receptor signaling pathwayIMPbiological_process
GO:0070577Histone acetyl-lysine bindingIDAmolecular_function
GO:0071564NpBAF complexIDA ISScellular_component
GO:0071565NBAF complexISScellular_component
GO:0071778WINAC complexIDAcellular_component
GO:2000134Negative regulation of G1/S transition of mitotic cell cycleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.32498245890.47814055320.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0899826331
GSE13712_SHEARUp0.0457879026
GSE13712_STATICUp0.0619992761
GSE19018Down-0.1117452656
GSE19899_A1Up0.0243341490
GSE19899_A2Up0.1158492958
PubMed_21979375_A1Up0.3124091281
PubMed_21979375_A2Up0.2701813659
GSE35957Down-0.4703397537
GSE36640Down-0.4408318749
GSE54402Up0.1904819580
GSE9593Down-0.4111231619
GSE43922Up0.1258270013
GSE24585Down-0.3845854442
GSE37065Down-0.1883251328
GSE28863_A1Up0.4293391910
GSE28863_A2Up0.4680681976
GSE28863_A3Up0.3374308704
GSE28863_A4Up0.1453565649
GSE48662Down-0.1955910412

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT006516Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21317927
hsa-miR-155-5pMIMAT0000646MIRT020993Reporter assay;OtherFunctional MTI20584899
hsa-miR-34a-5pMIMAT0000255MIRT025405ProteomicsFunctional MTI (Weak)21566225
hsa-miR-98-5pMIMAT0000096MIRT027823MicroarrayFunctional MTI (Weak)19088304
hsa-let-7b-5pMIMAT0000063MIRT032484ProteomicsFunctional MTI (Weak)18668040
hsa-let-7b-5pMIMAT0000063MIRT032484CLASHFunctional MTI (Weak)23622248
hsa-miR-342-5pMIMAT0004694MIRT038217CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039649CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046781CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051309CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23438604BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss
23438604BRG1 is a chromatin-remodeling factor that interacts with BRCA1 and pRB
23438604Here we show that BRG1 is required for SAHF formation and senescence induced by oncogenic RAS or BRCA1 loss
23438604The interaction between BRG1 and BRCA1 is disrupted during senescence
23438604This correlates with an increased level of chromatin-associated BRG1 in senescent cells
23438604BRG1 knockdown suppresses the formation of SAHF and senescence, while it has no effect on BRCA1 chromatin dissociation induced by oncogenic RAS, indicating that BRG1 functions downstream of BRCA1 chromatin dissociation
23438604Furthermore, BRG1 knockdown inhibits SAHF formation and senescence induced by BRCA1 knockdown
23438604Conversely, BRG1 overexpression drives SAHF formation and senescence in a DNA damage-independent manner
23438604This effect depends upon BRG1's chromatin-remodeling activity as well as the interaction between BRG1 and pRB
23438604Indeed, the interaction between BRG1 and pRB is enhanced during senescence
23438604Consistently, knockdown of pRB, p21(CIP1), and p16(INK4a), but not p53, suppressed SAHF formation induced by BRG1
23438604Together, these studies reveal the molecular underpinning by which BRG1 acts downstream of BRCA1 to promote SAHF formation and senescence
22563078Second, MSP58, p53, and the SWI/SNF chromatin-remodeling subunit Brahma-related gene 1 (BRG1) form a ternary complex on the p21 promoter and collaborate to activate p21
20697355The BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB-P53 pathways
20697355We focused our attention on brahma-related gene 1 (BRG1), the ATPase subunit of the SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeling complex, and analyzed its role in mesenchymal stem cell (MSC) biology
20697355We wanted to know what would happen if a cell had to cope with altered regulation of gene expression, either by upregulation or downregulation of BRG1
20697355Knockdown of BRG1 expression induced a significant increase in senescent cells and decrease in apoptotic cells
20697355It is interesting that BRG1 downregulation also induced an increase in heterochromatin
20697355This is consistent with our previous research, which showed that BRG1 upregulation by ectopic expression also induced senescence processes
20697355Together, these data suggest that BRG1 belongs to a class of genes whose expression is tightly regulated; hence, subtle alterations in BRG1 activity seem to negatively affect mechanisms regulating chromatin status and, in turn, impair cellular physiology
19448667The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells
19448667Mammalian SWI/SNF remodeling complexes incorporate either the Brahma-related gene 1 (BRG1) or Brahma (Brm) as the ATPase subunit
19448667The observation that tumor cell lines harboring wild-type p53 specifically maintain expression of BRG1 and that BRG1 complexes with p53 prompted us to examine the role of BRG1 in regulation of p53
18332116Gene activation by hSNF5 is strictly dependent on the SWI/SNF motor subunit BRG1
14729964BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI
14729964It was suggested that the direct interaction of BRG1 with the retinoblastoma protein pRB is required for regulation of cell cycle progression by pRB
14729964Furthermore, we show that the physical interaction between BRG1 and pRB is not required for induction of cell growth arrest and transcriptional repression of E2F target genes by pRB
14729964Instead, BRG1 activates pRB by inducing its hypophosphorylation through up-regulation of the cdk inhibitor p21
14729964We demonstrate that up-regulation of p21 by BRG1 is necessary to induce formation of flat cells, growth arrest, and finally, cell senescence
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