HCSGD entry for SMARCA1
1. General information
| Official gene symbol | SMARCA1 |
|---|---|
| Entrez ID | 6594 |
| Gene full name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 |
| Other gene symbols | ISWI NURF140 SNF2L SNF2L1 SNF2LB SNF2LT SWI SWI2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000733 | DNA strand renaturation | IDA | biological_process |
| GO:0000790 | Nuclear chromatin | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004386 | Helicase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006338 | Chromatin remodeling | IDA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IMP | biological_process |
| GO:0007420 | Brain development | IMP | biological_process |
| GO:0008094 | DNA-dependent ATPase activity | IDA | molecular_function |
| GO:0016589 | NURF complex | IDA | cellular_component |
| GO:0030182 | Neuron differentiation | IEA ISS | biological_process |
| GO:0031491 | Nucleosome binding | IEA | molecular_function |
| GO:0036310 | Annealing helicase activity | IDA | molecular_function |
| GO:0043044 | ATP-dependent chromatin remodeling | IDA IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0070615 | Nucleosome-dependent ATPase activity | IDA | molecular_function |
| GO:0090537 | CERF complex | IDA | cellular_component |
| GO:2000177 | Regulation of neural precursor cell proliferation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7905009194 | 0.0262654382 | 0.9999902473 | 0.3108509892 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4487816881 |
| GSE13712_SHEAR | Down | -0.3331791860 |
| GSE13712_STATIC | Down | -0.1875659464 |
| GSE19018 | Up | 0.4847805828 |
| GSE19899_A1 | Down | -0.0926257651 |
| GSE19899_A2 | Down | -0.6342135760 |
| PubMed_21979375_A1 | Down | -1.0326072804 |
| PubMed_21979375_A2 | Down | -0.6197561372 |
| GSE35957 | Down | -0.0442510001 |
| GSE36640 | Down | -0.0437116063 |
| GSE54402 | Down | -0.3960030044 |
| GSE9593 | Down | -0.1474940051 |
| GSE43922 | Down | -0.3052959487 |
| GSE24585 | Up | 0.4206088084 |
| GSE37065 | Down | -0.2907790128 |
| GSE28863_A1 | Up | 0.3749901336 |
| GSE28863_A2 | Up | 0.3163938855 |
| GSE28863_A3 | Down | -0.9560769944 |
| GSE28863_A4 | Up | 0.2826854839 |
| GSE48662 | Down | -0.0559544079 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019340 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021323 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-1 | MIMAT0000416 | MIRT023690 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028492 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032345 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26992241 | BAF180 (also called PBRM1), a subunit of the SWI/SNF complex, plays critical roles in the regulation of chromatin remodeling and gene transcription, and is frequently mutated in several human cancers |
| 20697355 | We focused our attention on brahma-related gene 1 (BRG1), the ATPase subunit of the SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeling complex, and analyzed its role in mesenchymal stem cell (MSC) biology |
| 19448667 | The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells |
| 19448667 | Mammalian SWI/SNF remodeling complexes incorporate either the Brahma-related gene 1 (BRG1) or Brahma (Brm) as the ATPase subunit |
| 18332116 | MRTs are extremely aggressive cancers caused by the loss of the hSNF5 subunit of the SWI/SNF chromatin-remodeling complex |
| 18332116 | Here, we investigated how the balance between Polycomb group (PcG) silencing and SWI/SNF activation affects epigenetic control of the INK4b-ARF-INK4a locus in MRT cells |
| 18332116 | Thus, various chromatin states can be modulated by SWI/SNF action |
| 17026941 | Furthermore, chromatin remodelling involving SWI/SNF complex, antagonist to Bmi-1, might activate INK4a expression |
| 14729964 | The ubiquitous mammalian chromatin-remodeling SWI/SNF-like BAF complexes play critical roles in tumorigenesis |
| 14604992 | Chromatin immunoprecipitations indicated that hSNF5 activates p16(INK4a) transcription and CD44 down-regulation by mediating recruitment of the SWI/SNF complex |
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