HCSGD entry for SLPI
1. General information
| Official gene symbol | SLPI |
|---|---|
| Entrez ID | 6590 |
| Gene full name | secretory leukocyte peptidase inhibitor |
| Other gene symbols | ALK1 ALP BLPI HUSI HUSI-I MPI WAP4 WFDC4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004866 | Endopeptidase inhibitor activity | TAS | molecular_function |
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0010951 | Negative regulation of endopeptidase activity | TAS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0032091 | Negative regulation of protein binding | IDA | biological_process |
| GO:0045071 | Negative regulation of viral genome replication | IDA | biological_process |
| GO:0052548 | Regulation of endopeptidase activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0681648646 | 0.8558455986 | 0.5612215735 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0435430480 |
| GSE13712_SHEAR | Down | -0.0881263085 |
| GSE13712_STATIC | Down | -0.0097386561 |
| GSE19018 | Up | 0.0385783442 |
| GSE19899_A1 | Up | 0.0644643125 |
| GSE19899_A2 | Up | 0.1108527567 |
| PubMed_21979375_A1 | Up | 0.1107173413 |
| PubMed_21979375_A2 | Down | -0.0378013378 |
| GSE35957 | Up | 0.2160120504 |
| GSE36640 | Up | 0.0185382901 |
| GSE54402 | Down | -0.1183755671 |
| GSE9593 | Up | 0.2770111435 |
| GSE43922 | Up | 0.0278487957 |
| GSE24585 | Up | 0.7997827858 |
| GSE37065 | Up | 1.6098870561 |
| GSE28863_A1 | Down | -0.0918696853 |
| GSE28863_A2 | Down | -0.1886331715 |
| GSE28863_A3 | Up | 0.2250999324 |
| GSE28863_A4 | Up | 0.1325437580 |
| GSE48662 | Up | 0.5318306953 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018178 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-146a-5p | MIMAT0000449 | MIRT021280 | Western blot;qRT-PCR | Functional MTI | 20110513 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
