HCSGD entry for BMPR2
1. General information
| Official gene symbol | BMPR2 |
|---|---|
| Entrez ID | 659 |
| Gene full name | bone morphogenetic protein receptor, type II (serine/threonine kinase) |
| Other gene symbols | BMPR-II BMPR3 BMR2 BRK-3 PPH1 T-ALK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001707 | Mesoderm formation | ISS | biological_process |
| GO:0001934 | Positive regulation of protein phosphorylation | IMP | biological_process |
| GO:0001938 | Positive regulation of endothelial cell proliferation | IMP | biological_process |
| GO:0001946 | Lymphangiogenesis | ISS | biological_process |
| GO:0001974 | Blood vessel remodeling | ISS | biological_process |
| GO:0003085 | Negative regulation of systemic arterial blood pressure | IMP | biological_process |
| GO:0005024 | Transforming growth factor beta-activated receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0005901 | Caveola | IMP | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0007178 | Transmembrane receptor protein serine/threonine kinase signaling pathway | IDA | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0009267 | Cellular response to starvation | IEP | biological_process |
| GO:0009925 | Basal plasma membrane | IEA | cellular_component |
| GO:0009952 | Anterior/posterior pattern specification | ISS | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0010595 | Positive regulation of endothelial cell migration | IMP | biological_process |
| GO:0010634 | Positive regulation of epithelial cell migration | IDA | biological_process |
| GO:0010862 | Positive regulation of pathway-restricted SMAD protein phosphorylation | IMP | biological_process |
| GO:0014916 | Regulation of lung blood pressure | IMP ISS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0016362 | Activin receptor activity, type II | TAS | molecular_function |
| GO:0019838 | Growth factor binding | IEA | molecular_function |
| GO:0030308 | Negative regulation of cell growth | IDA | biological_process |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0030501 | Positive regulation of bone mineralization | IMP | biological_process |
| GO:0030509 | BMP signaling pathway | IDA IMP ISS TAS | biological_process |
| GO:0030513 | Positive regulation of BMP signaling pathway | IMP | biological_process |
| GO:0032924 | Activin receptor signaling pathway | TAS | biological_process |
| GO:0042127 | Regulation of cell proliferation | IMP | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0045669 | Positive regulation of osteoblast differentiation | IMP | biological_process |
| GO:0045906 | Negative regulation of vasoconstriction | ISS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048010 | Vascular endothelial growth factor receptor signaling pathway | ISS | biological_process |
| GO:0048286 | Lung alveolus development | ISS | biological_process |
| GO:0060836 | Lymphatic endothelial cell differentiation | ISS | biological_process |
| GO:0060840 | Artery development | ISS | biological_process |
| GO:0060841 | Venous blood vessel development | ISS | biological_process |
| GO:0061298 | Retina vasculature development in camera-type eye | ISS | biological_process |
| GO:2000279 | Negative regulation of DNA biosynthetic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1671587364 | 0.0889694237 | 0.8069545388 | 0.5659169164 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3376883139 |
| GSE13712_SHEAR | Up | 0.1650987883 |
| GSE13712_STATIC | Up | 0.0339603340 |
| GSE19018 | Down | -0.3636021005 |
| GSE19899_A1 | Down | -0.2298903194 |
| GSE19899_A2 | Down | -0.5565625824 |
| PubMed_21979375_A1 | Down | -0.9437354583 |
| PubMed_21979375_A2 | Down | -0.0103460848 |
| GSE35957 | Up | 0.2124982983 |
| GSE36640 | Up | 0.4999426979 |
| GSE54402 | Down | -0.1569515189 |
| GSE9593 | Up | 0.3138204814 |
| GSE43922 | Down | -0.3405242140 |
| GSE24585 | Up | 1.3849876030 |
| GSE37065 | Up | 0.2564718761 |
| GSE28863_A1 | Up | 0.6630799834 |
| GSE28863_A2 | Up | 0.7234227321 |
| GSE28863_A3 | Down | -0.3649524215 |
| GSE28863_A4 | Down | -0.5113645634 |
| GSE48662 | Down | -0.2101457231 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-20a-5p | MIMAT0000075 | MIRT000181 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19390056 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003837 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19578724 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003837 | Luciferase reporter assay//qRT-PCR | Functional MTI | 18829576 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT003837 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-129-5p | MIMAT0000242 | MIRT004051 | In situ hybridization//Microarray//qRT-PCR | Non-Functional MTI (Weak) | 19487295 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT004932 | Luciferase reporter assay//qRT-PCR//Western blot | Non-Functional MTI | 19390056 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT004933 | Luciferase reporter assay//qRT-PCR//Western blot | Non-Functional MTI | 19390056 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT004934 | Luciferase reporter assay//qRT-PCR//Western blot | Non-Functional MTI | 19390056 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT004935 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19390056 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT006723 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22684006 |
| hsa-miR-302c-3p | MIMAT0000717 | MIRT006970 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 22988237 |
| hsa-miR-130a-3p | MIMAT0000425 | MIRT007142 | qRT-PCR | Functional MTI (Weak) | 23418453 |
| hsa-miR-181c-5p | MIMAT0000258 | MIRT007221 | Luciferase reporter assay | Functional MTI | 23352489 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021896 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024599 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025637 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026148 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT027982 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028861 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028861 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038729 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | NA | hsa-miR-21 | 17991735 | |||
| hsa-miR-21-5p | MIMAT0000076 | 3 | hsa-miR-21 | {Western blot} | {endogenous} | 19578724 | |
| hsa-miR-21-5p | MIMAT0000076 | 4 | hsa-miR-21 | {Western blot} | {endogenous} | 19578724 | |
| hsa-miR-21-5p | MIMAT0000076 | 2 | hsa-miR-21 | {Western blot} | {endogenous} | 19578724 | |
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | {Western blot} | {endogenous} | 19578724 | |
| hsa-miR-129-5p | MIMAT0000242 | NA | hsa-miR-129-5p | 19487295 | |||
| hsa-miR-19a-3p | MIMAT0000073 | 2 | hsa-miR-19a | {Western blot} | {overexpression by miRNA precursor transfection} | 19390056 | |
| hsa-miR-19a-3p | MIMAT0000073 | 1 | hsa-miR-19a | {Western blot} | {overexpression by miRNA precursor transfection} | 19390056 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
