HCSGD entry for SLC22A4

1. General information

Official gene symbolSLC22A4
Entrez ID6583
Gene full namesolute carrier family 22 (organic cation/ergothioneine transporter), member 4
Other gene symbolsOCTN1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingTASmolecular_function
GO:0003333Amino acid transmembrane transportIDAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005886Plasma membraneIC TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006641Triglyceride metabolic processIEAbiological_process
GO:0006814Sodium ion transportIEAbiological_process
GO:0007589Body fluid secretionTASbiological_process
GO:0008513Secondary active organic cation transmembrane transporter activityTASmolecular_function
GO:0009437Carnitine metabolic processIEAbiological_process
GO:0015226Carnitine transmembrane transporter activityIDAmolecular_function
GO:0015293Symporter activityIEAmolecular_function
GO:0015491Cation:cation antiporter activityIDAmolecular_function
GO:0015651Quaternary ammonium group transmembrane transporter activityIDAmolecular_function
GO:0015695Organic cation transportTASbiological_process
GO:0015697Quaternary ammonium group transportIDAbiological_process
GO:0015879Carnitine transportIDAbiological_process
GO:0016324Apical plasma membraneIDAcellular_component
GO:0030165PDZ domain bindingIPImolecular_function
GO:0055085Transmembrane transportTASbiological_process
GO:0072337Modified amino acid transportIDAbiological_process
GO:1902603Carnitine transmembrane transportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00003116900.97750313440.01547924531.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up2.4755676714
GSE13712_SHEARUp0.3992677117
GSE13712_STATICUp0.2409752254
GSE19018Up0.4191778016
GSE19899_A1Up1.6468472853
GSE19899_A2Up2.6264341117
PubMed_21979375_A1Up4.2069372307
PubMed_21979375_A2Up2.8886568446
GSE35957Up2.4651791510
GSE36640Up2.8248962260
GSE54402Up1.6178263833
GSE9593Up0.3506823260
GSE43922Up0.9709906175
GSE24585Up0.0778521680
GSE37065Up0.7071452891
GSE28863_A1Down-0.3624033375
GSE28863_A2Up0.9014164550
GSE28863_A3Down-0.0154381263
GSE28863_A4Down-0.2411129104
GSE48662Down-0.6594933124

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-CarnitineDB00583 APRD01070

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.