HCSGD entry for SLC8A1

1. General information

Official gene symbolSLC8A1
Entrez ID6546
Gene full namesolute carrier family 8 (sodium/calcium exchanger), member 1
Other gene symbolsNCX1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001892Embryonic placenta developmentIEAbiological_process
GO:0002026Regulation of the force of heart contractionIC IEA ISSbiological_process
GO:0002027Regulation of heart rateISSbiological_process
GO:0003007Heart morphogenesisIEAbiological_process
GO:0005432Calcium:sodium antiporter activityIDA IEAmolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006811Ion transportTASbiological_process
GO:0006936Muscle contractionTASbiological_process
GO:0007154Cell communicationIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008092Cytoskeletal protein bindingIDAmolecular_function
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0010881Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionISSbiological_process
GO:0014704Intercalated discISScellular_component
GO:0014829Vascular smooth muscle contractionISSbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0030018Z discISScellular_component
GO:0030315T-tubuleIEA ISScellular_component
GO:0030506Ankyrin bindingIPI ISSmolecular_function
GO:0034614Cellular response to reactive oxygen speciesIDAbiological_process
GO:0035050Embryonic heart tube developmentIEAbiological_process
GO:0042383SarcolemmaISScellular_component
GO:0044325Ion channel bindingISSmolecular_function
GO:0044557Relaxation of smooth muscleISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048747Muscle fiber developmentIEAbiological_process
GO:0051481Negative regulation of cytosolic calcium ion concentrationISSbiological_process
GO:0055013Cardiac muscle cell developmentIEA ISSbiological_process
GO:0055074Calcium ion homeostasisISSbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0055119Relaxation of cardiac muscleICbiological_process
GO:0060048Cardiac muscle contractionIEAbiological_process
GO:0060401Cytosolic calcium ion transportTASbiological_process
GO:0060402Calcium ion transport into cytosolISSbiological_process
GO:0070509Calcium ion importIDAbiological_process
GO:0071313Cellular response to caffeineISSbiological_process
GO:0071436Sodium ion exportIDAbiological_process
GO:0086064Cell communication by electrical coupling involved in cardiac conductionISSbiological_process
GO:0097369Sodium ion importIDAbiological_process
GO:1901660Calcium ion exportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99531221080.00012142020.99999024730.0197282209

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5615268196
GSE13712_SHEARUp0.0285547569
GSE13712_STATICDown-0.0043347852
GSE19018Down-0.0085131379
GSE19899_A1Down-0.5524632518
GSE19899_A2Down-1.6247199396
PubMed_21979375_A1Down-2.3278985132
PubMed_21979375_A2Down-1.4334100238
GSE35957Up0.0667777276
GSE36640Down-0.5760186359
GSE54402Down-1.4366369972
GSE9593Up0.0156173761
GSE43922Down-2.5987698663
GSE24585Down-0.0315454686
GSE37065Down-0.5187977700
GSE28863_A1Down-0.8365140281
GSE28863_A2Down-1.4755817313
GSE28863_A3Down-0.8898931268
GSE28863_A4Down-0.5409734322
GSE48662Up0.2623712449

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.