HCSGD entry for NCF1

1. General information

Official gene symbolNCF1
Entrez ID653361
Gene full nameneutrophil cytosolic factor 1
Other gene symbolsNCF1A NOXO2 SH3PXD1A p47phox
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001878Response to yeastIEAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0002679Respiratory burst involved in defense responseIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005791Rough endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006612Protein targeting to membraneIDAbiological_process
GO:0006691Leukotriene metabolic processIEAbiological_process
GO:0006801Superoxide metabolic processTASbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006968Cellular defense responseIEAbiological_process
GO:0007154Cell communicationIEAbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0009055Electron carrier activityTASmolecular_function
GO:0016175Superoxide-generating NADPH oxidase activityIEA IMPmolecular_function
GO:0017124SH3 domain bindingIPImolecular_function
GO:0019898Extrinsic component of membraneIDAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0032010PhagolysosomeTAScellular_component
GO:0035091Phosphatidylinositol bindingIDA IEAmolecular_function
GO:0042554Superoxide anion generationIMP TASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0043020NADPH oxidase complexIDA TAScellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043325Phosphatidylinositol-3,4-bisphosphate bindingIDAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045730Respiratory burstTASbiological_process
GO:0045986Negative regulation of smooth muscle contractionIEAbiological_process
GO:0050665Hydrogen peroxide biosynthetic processIEAbiological_process
GO:0051701Interaction with hostTASbiological_process
GO:0055114Oxidation-reduction processIMPbiological_process
GO:0070946Neutrophil mediated killing of gram-positive bacteriumIEAbiological_process
GO:0070947Neutrophil mediated killing of fungusIEAbiological_process
GO:0090382Phagosome maturationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31264329620.96489685040.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.4607350262
GSE28863_A2Up0.1206218451
GSE28863_A3Down-0.1002383105
GSE28863_A4Up0.1220502729
GSE48662Up0.0594498482

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DextromethorphanDB00514 APRD00655

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25922068Here, we utilized a p47(phox) knock-out mouse model, in which an essential cytosolic co-activator of Nox2 is lost, to characterize bone metabolism at 6 weeks and 2 years of age
25922068Compared with their age-matched wild type controls, loss of Nox2 function in p47(phox-/-) mice resulted in age-related switch of bone mass and strength
25922068Differences in bone mass were associated with increased bone formation in 6-week-old p47(phox-/-) mice but decreased in 2-year-old p47(phox-/-) mice
25922068Despite decreases in ROS generation in bone marrow cells and p47(phox)-Nox2 signaling in osteoblastic cells, 2-year-old p47(phox-/-) mice showed increased senescence-associated secretory phenotype in bone compared with their wild type controls
25922068These in vivo findings were mechanistically recapitulated in ex vivo cell culture of primary fetal calvarial cells from p47(phox-/-) mice
25192254BMC treatment also attenuated NADPH oxidase subunits p47phox and gp91phox expression, and significantly reduced ROS formation, apoptosis, fibrosis and hypertrophy in post-MI mice
22284404Res protected against HFS- or high-glucose-induced increase in NADPH oxidase p47phox expression and decrease in SIRT1 level
22284404Apocynin, a NADPH oxidase inhibitor, down-regulated p47phox protein expression, but had no influence on SIRT1 protein; sirtinol, a SIRT1 inhibitor, aggravated the decrease in SIRT1 protein level and the increase in p47phox protein expression induced by high glucose
19777843Western blot were used to analyse protein expression of NADPH oxidase p47phox, angiotensin type 1 and 2 receptor (AT1R, AT2R)
19777843Protein expression of p47phox, AT1R and AT2R in cells increased compared with Vit E group
19777843Protein expression of p47phox, AT1R and AT2R in cells treated with Chinese herbs of high dose and low dose were decreased compared with Vit E group
18239191The mechanism underlying this finding was associated with decreased NF-kappaB activation, and reactive oxygen species generation by decreased phosphorylation of p47(phox) and down-modulating the activation of p21-activated kinase
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