HCSGD entry for UCA1
1. General information
| Official gene symbol | UCA1 |
|---|---|
| Entrez ID | 652995 |
| Gene full name | urothelial cancer associated 1 (non-protein coding) |
| Other gene symbols | CUDR LINC00178 NCRNA00178 UCAT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
Not in the Gene ontology4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6808496562 | 0.4789223548 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0095240093 |
| GSE13712_SHEAR | Down | -0.1046694925 |
| GSE13712_STATIC | Down | -0.0868597433 |
| GSE19018 | Down | -0.1570915148 |
| GSE19899_A1 | Up | 0.2933243212 |
| GSE19899_A2 | Up | 0.3895878295 |
| PubMed_21979375_A1 | Up | 0.0390565434 |
| PubMed_21979375_A2 | Down | -0.0966022367 |
| GSE35957 | Down | -0.0047494716 |
| GSE36640 | Up | 0.0295963652 |
| GSE54402 | Down | -0.1214141937 |
| GSE9593 | Up | 0.1837164791 |
| GSE43922 | Up | 0.0160403323 |
| GSE24585 | Down | -0.0440428936 |
| GSE37065 | Up | 0.1299766715 |
| GSE28863_A1 | Down | -0.3234979753 |
| GSE28863_A2 | Down | -0.3872256554 |
| GSE28863_A3 | Down | -0.0737776688 |
| GSE28863_A4 | Up | 0.1807811972 |
| GSE48662 | Up | 0.0567517071 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24876127 | The IncRNA UCA1 is a direct target of CAPERalpha/TBX3 repression whose overexpression is sufficient to induce senescence |
| 24876127 | In proliferating cells, we found that hnRNPA1 binds and destabilizes CDKN2A-p16INK mRNA whereas during senescence, UCA1 sequesters hnRNPA1 and thus stabilizes CDKN2A-p16INK |
| 24876127 | Thus CAPERalpha/TBX3 and UCA1 constitute a coordinated, reinforcing mechanism to regulate both CDKN2A-p16INK transcription and mRNA stability |
| 24876127 | Dissociation of the CAPERalpha/TBX3 co-repressor during oncogenic stress activates UCA1, revealing a novel mechanism for oncogene-induced senescence |
| 24876127 | Our elucidation of CAPERalpha and UCA1 functions in vivo provides new insights into senescence induction, and the oncogenic and developmental properties of TBX3 |
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