HCSGD entry for WNK2

1. General information

Official gene symbolWNK2
Entrez ID65268
Gene full nameWNK lysine deficient protein kinase 2
Other gene symbolsNY-CO-43 P/OKcl.13 PRKWNK2 SDCCAG43
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004674Protein serine/threonine kinase activityIEA ISSmolecular_function
GO:0005524ATP bindingIEA ISSmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0035556Intracellular signal transductionISSbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:2000021Regulation of ion homeostasisIMPbiological_process
GO:2000651Positive regulation of sodium ion transmembrane transporter activityIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45664622920.89873425020.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0393565067
GSE13712_SHEARDown-0.0083266956
GSE13712_STATICDown-0.0043826004
GSE19018Up0.1542692594
GSE19899_A1Up0.1211781794
GSE19899_A2Up0.1281598612
PubMed_21979375_A1Up0.0265456023
PubMed_21979375_A2Up0.0167308277
GSE35957Up0.0852672754
GSE36640Up0.1306632237
GSE54402Up0.0088728668
GSE9593Up0.0681588503
GSE43922Up0.0580369634
GSE24585Down-0.0858604696
GSE37065Down-0.1123332291
GSE28863_A1Up0.0221081282
GSE28863_A2Up0.0466369704
GSE28863_A3Up0.3944589372
GSE28863_A4Down-0.0350154092
GSE48662Down-0.0118148765

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.