HCSGD entry for WNK3
1. General information
| Official gene symbol | WNK3 |
|---|---|
| Entrez ID | 65267 |
| Gene full name | WNK lysine deficient protein kinase 3 |
| Other gene symbols | PRKWNK3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | ISS | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005912 | Adherens junction | ISS | cellular_component |
| GO:0005923 | Tight junction | ISS | cellular_component |
| GO:0006468 | Protein phosphorylation | ISS | biological_process |
| GO:0010765 | Positive regulation of sodium ion transport | IDA | biological_process |
| GO:0010800 | Positive regulation of peptidyl-threonine phosphorylation | IDA | biological_process |
| GO:0032414 | Positive regulation of ion transmembrane transporter activity | IDA | biological_process |
| GO:0035556 | Intracellular signal transduction | ISS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0051928 | Positive regulation of calcium ion transport | IMP | biological_process |
| GO:0090004 | Positive regulation of establishment of protein localization to plasma membrane | IDA | biological_process |
| GO:2000021 | Regulation of ion homeostasis | IMP | biological_process |
| GO:2000651 | Positive regulation of sodium ion transmembrane transporter activity | IDA IMP | biological_process |
| GO:2000682 | Positive regulation of rubidium ion transport | IDA | biological_process |
| GO:2000688 | Positive regulation of rubidium ion transmembrane transporter activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8995697428 | 0.1558771893 | 0.9999902473 | 0.7626545978 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0071086997 |
| GSE13712_SHEAR | Down | -0.2691284355 |
| GSE13712_STATIC | Down | -0.2810362403 |
| GSE19018 | Down | -0.6612596978 |
| GSE19899_A1 | Up | 0.2050463283 |
| GSE19899_A2 | Down | -0.1097307419 |
| PubMed_21979375_A1 | Down | -0.1076974781 |
| PubMed_21979375_A2 | Down | -0.0744507191 |
| GSE35957 | Down | -0.4812630925 |
| GSE36640 | Down | -0.1546578506 |
| GSE54402 | Up | 0.0543691599 |
| GSE9593 | Up | 0.0957012737 |
| GSE43922 | Up | 0.0155065229 |
| GSE24585 | Down | -0.3383647984 |
| GSE37065 | Up | 0.2336572390 |
| GSE28863_A1 | Up | 0.1275982745 |
| GSE28863_A2 | Up | 0.3506968099 |
| GSE28863_A3 | Down | -0.3677434566 |
| GSE28863_A4 | Down | -0.0816382534 |
| GSE48662 | Down | -0.0532210086 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT031069 | Microarray | Functional MTI (Weak) | 21544242 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045734 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT047011 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
