HCSGD entry for SLC5A2
1. General information
| Official gene symbol | SLC5A2 |
|---|---|
| Entrez ID | 6524 |
| Gene full name | solute carrier family 5 (sodium/glucose cotransporter), member 2 |
| Other gene symbols | SGLT2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005215 | Transporter activity | IEA | molecular_function |
| GO:0005362 | Low-affinity glucose:sodium symporter activity | TAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0015749 | Monosaccharide transport | TAS | biological_process |
| GO:0015758 | Glucose transport | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0034219 | Carbohydrate transmembrane transport | TAS | biological_process |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0035428 | Hexose transmembrane transport | TAS | biological_process |
| GO:0035725 | Sodium ion transmembrane transport | TAS | biological_process |
| GO:0055085 | Transmembrane transport | IEA TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9337103530 | 0.2452354508 | 0.9999902473 | 0.9535160714 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2151053143 |
| GSE13712_SHEAR | Down | -0.2323006357 |
| GSE13712_STATIC | Down | -0.0360458541 |
| GSE19018 | Down | -0.1434557029 |
| GSE19899_A1 | Down | -0.0791839996 |
| GSE19899_A2 | Up | 0.1130237548 |
| PubMed_21979375_A1 | Down | -0.1303860427 |
| PubMed_21979375_A2 | Down | -0.1043129580 |
| GSE35957 | Up | 0.0146123618 |
| GSE36640 | Down | -0.0724097781 |
| GSE54402 | Down | -0.1022282922 |
| GSE9593 | Up | 0.0863612471 |
| GSE43922 | Up | 0.1330161542 |
| GSE24585 | Down | -0.0255717121 |
| GSE37065 | Down | -0.1162695358 |
| GSE28863_A1 | Down | -0.2764496713 |
| GSE28863_A2 | Down | -0.3471201663 |
| GSE28863_A3 | Up | 0.1852657706 |
| GSE28863_A4 | Down | -0.0178422063 |
| GSE48662 | Up | 0.2551604619 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24996978 | Hyperglycemia causes cellular senescence via a SGLT2 in proximal tubules in the early stage of diabetic nephropathy |
| 24996978 | CONCLUSIONS: These results suggest that hyperglycemia causes tubular senescence via a SGLT2- and p21-dependent pathway in the type 1 diabetic kidney |
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