HCSGD entry for SLC4A1

1. General information

Official gene symbolSLC4A1
Entrez ID6521
Gene full namesolute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
Other gene symbolsAE1 BND3 CD233 DI EMPB3 EPB3 FR RTA1A SW WD WD1 WR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003779Actin bindingIEAmolecular_function
GO:0005452Inorganic anion exchanger activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006811Ion transportTASbiological_process
GO:0006820Anion transportIDAbiological_process
GO:0006821Chloride transportISSbiological_process
GO:0006873Cellular ion homeostasisTASbiological_process
GO:0008022Protein C-terminus bindingIEAmolecular_function
GO:0008509Anion transmembrane transporter activityTASmolecular_function
GO:0015108Chloride transmembrane transporter activityISSmolecular_function
GO:0015301Anion:anion antiporter activityIDAmolecular_function
GO:0015701Bicarbonate transportTASbiological_process
GO:0016021Integral component of membraneNAScellular_component
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0030018Z discISScellular_component
GO:0030506Ankyrin bindingIPImolecular_function
GO:0030863Cortical cytoskeletonIDAcellular_component
GO:0034220Ion transmembrane transportIDA ISS TASbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043495Protein anchorTASmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:1902476Chloride transmembrane transportISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40897606470.97635984950.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0320842994
GSE13712_SHEARUp0.0018103220
GSE13712_STATICUp0.1466072814
GSE19018Up0.1241262163
GSE19899_A1Up0.1300178827
GSE19899_A2Up0.1298143851
PubMed_21979375_A1Up0.1434898055
PubMed_21979375_A2Down-0.1417449981
GSE35957Up0.2691806248
GSE36640Up0.0650150784
GSE54402Up0.0020882022
GSE9593Up0.0958336680
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.1195162025

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19238475Derangement of erythrocytic AE1 in beta-thalassemia by caspase 3: pathogenic mechanisms and implications in red blood cell senescence
16399889A residue that is close to that region was identified in mouse AE1 ASGPGAAAQIQEVK, residue 762-775
14872535These findings suggest that other isoforms of band 3 may undergo the same aging changes that AE1 on red blood cells undergoes to generate SCA
9850933These epitopes correspond to regions in the membrane domain that are involved in generation of senescent cell-specific antigen from AE1 in aging erythrocytes
9721076The aim of this study was to evaluate in vitro the modifications in the profile of erythrocyte membrane protein band 3 (monomer, aggregates and fragments) imposed by cellular aging, by activated neutrophils (AN) and by neutrophilic elastase
8996830These epitopes correspond to regions in the membrane domain that are involved in generation of senescent cell-specific antigen from AE1 in aging erythrocytes
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