HCSGD entry for SLC3A2

1. General information

Official gene symbolSLC3A2
Entrez ID6520
Gene full namesolute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Other gene symbols4F2 4F2HC 4T2HC CD98 CD98HC MDU1 NACAE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003333Amino acid transmembrane transportISSbiological_process
GO:0003725Double-stranded RNA bindingIDAmolecular_function
GO:0003824Catalytic activityIEAmolecular_function
GO:0005432Calcium:sodium antiporter activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005975Carbohydrate metabolic processIEAbiological_process
GO:0006811Ion transportTASbiological_process
GO:0006816Calcium ion transportNASbiological_process
GO:0006865Amino acid transportTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0015175Neutral amino acid transmembrane transporter activityIEA ISSmolecular_function
GO:0015672Monovalent inorganic cation transportTASbiological_process
GO:0015827Tryptophan transportISSbiological_process
GO:0016021Integral component of membraneNAScellular_component
GO:0016049Cell growthNASbiological_process
GO:0016324Apical plasma membraneIEAcellular_component
GO:0034220Ion transmembrane transportISS TASbiological_process
GO:0035725Sodium ion transmembrane transportTASbiological_process
GO:0042470MelanosomeIEAcellular_component
GO:0043169Cation bindingIEAmolecular_function
GO:0043330Response to exogenous dsRNAIMPbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060356Leucine importIEA ISSbiological_process
GO:0070588Calcium ion transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00977177920.92440986660.25226323531.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.0463019778
GSE13712_SHEARUp0.3449345048
GSE13712_STATICUp0.1484107844
GSE19018Up0.6475898173
GSE19899_A1Up0.1187258049
GSE19899_A2Down-0.0484884201
PubMed_21979375_A1Up2.8486874800
PubMed_21979375_A2Up0.3639726266
GSE35957Down-0.9716986386
GSE36640Up0.1459275324
GSE54402Up0.0440517205
GSE9593Up0.3718198645
GSE43922Up0.4167909615
GSE24585Up0.6413400518
GSE37065Up0.1543108575
GSE28863_A1Down-0.0111381602
GSE28863_A2Down-0.1147584279
GSE28863_A3Down-0.3957632947
GSE28863_A4Up0.0227336630
GSE48662Up0.3521828419

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029803MicroarrayFunctional MTI (Weak)19088304
hsa-miR-16-5pMIMAT0000069MIRT031815ProteomicsFunctional MTI (Weak)18668040
hsa-miR-193b-3pMIMAT0002819MIRT041531CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047602CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049624CLASHFunctional MTI (Weak)23622248
hsa-miR-1260bMIMAT0015041MIRT052758CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27259496The effect peptides KE, KED, AED and AEDG on proliferation (Ki-67), regeneration and aging (CD98hc), apoptosis (caspase-3), and extracellular matrix remodeling (MMP-9) in skin fibroblasts during their aging in culture were studied by immunofluorescent confocal microscopy
27259496All studied peptides inhibited MMP-9 synthesis that increases during aging of skin fibroblasts and enhanced the expression of Ki-67 and CD98hc that are less intensively synthesized during cell aging
26152646Estimated glomerular filtration rate (eGFR), 25(OH) D3, chronic kidney disease (CKD), the MYH9 (myosin heavy chain 9) gene in old and very elderly people
24984152To narrow down the functional domain of HKa, recombinant proteins of human HK heavy chain (HC, 19-380aa) and light chain (LC, 390-644aa) were generated
24028184RESULTS: Co-expression of alpha-smooth muscle actin and smooth muscle myosin heavy chain confirmed all cell populations as SMC
23933320METHODS: We generated transgenic mice with cardiac-specific overexpression of SMP30 gene using alpha-myosin heavy chain promoter
19436740It also activates immunoglobulin heavy chain transcription and engages in heterodimer formation with E2F to stimulate E2F-dependent transcription
1639144The 29-kDa peptide corresponds to the heavy chain of the two-chain enzyme form
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