HCSGD entry for BMP4

1. General information

Official gene symbolBMP4
Entrez ID652
Gene full namebone morphogenetic protein 4
Other gene symbolsBMP2B BMP2B1 MCOPS6 OFC11 ZYME
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000186Activation of MAPKK activityIDAbiological_process
GO:0001525AngiogenesisIEAbiological_process
GO:0001649Osteoblast differentiationIDAbiological_process
GO:0001657Ureteric bud developmentIDAbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisIDAbiological_process
GO:0001759Organ inductionIEAbiological_process
GO:0001822Kidney developmentIMPbiological_process
GO:0001823Mesonephros developmentIEPbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIDA IEAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIDAbiological_process
GO:0001958Endochondral ossificationIEA ISSbiological_process
GO:0002043Blood vessel endothelial cell proliferation involved in sprouting angiogenesisIDAbiological_process
GO:0002062Chondrocyte differentiationIEA ISSbiological_process
GO:0002244Hematopoietic progenitor cell differentiationIDAbiological_process
GO:0002320Lymphoid progenitor cell differentiationIMPbiological_process
GO:0003014Renal system processIEAbiological_process
GO:0003130BMP signaling pathway involved in heart inductionIMPbiological_process
GO:0003139Secondary heart field specificationIMPbiological_process
GO:0003197Endocardial cushion developmentTASbiological_process
GO:0003279Cardiac septum developmentTASbiological_process
GO:0003323Type B pancreatic cell developmentIDAbiological_process
GO:0003337Mesenchymal to epithelial transition involved in metanephros morphogenesisIDAbiological_process
GO:0005125Cytokine activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA ISS TAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIEA ISScellular_component
GO:0007182Common-partner SMAD protein phosphorylationIDAbiological_process
GO:0007224Smoothened signaling pathwayIEPbiological_process
GO:0007281Germ cell developmentIEAbiological_process
GO:0007500Mesodermal cell fate determinationIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008201Heparin bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0009791Post-embryonic developmentIDAbiological_process
GO:0009948Anterior/posterior axis specificationIEAbiological_process
GO:0010159Specification of organ positionIEAbiological_process
GO:0010595Positive regulation of endothelial cell migrationIDAbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIDA IMPbiological_process
GO:0010942Positive regulation of cell deathIDAbiological_process
GO:0021537Telencephalon developmentIDAbiological_process
GO:0021904Dorsal/ventral neural tube patterningIEAbiological_process
GO:0021978Telencephalon regionalizationIEAbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030218Erythrocyte differentiationIEAbiological_process
GO:0030224Monocyte differentiationIDAbiological_process
GO:0030225Macrophage differentiationIDAbiological_process
GO:0030501Positive regulation of bone mineralizationIDAbiological_process
GO:0030509BMP signaling pathwayIDA IMPbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEA ISSbiological_process
GO:0032092Positive regulation of protein bindingIDAbiological_process
GO:0032331Negative regulation of chondrocyte differentiationIEAbiological_process
GO:0032967Positive regulation of collagen biosynthetic processIDAbiological_process
GO:0033085Negative regulation of T cell differentiation in thymusIMPbiological_process
GO:0033088Negative regulation of immature T cell proliferation in thymusIMPbiological_process
GO:0034504Protein localization to nucleusIDAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0035990Tendon cell differentiationIEA ISSbiological_process
GO:0035993Deltoid tuberosity developmentIEA ISSbiological_process
GO:0040007GrowthIEAbiological_process
GO:0042056Chemoattractant activityIDAmolecular_function
GO:0042326Negative regulation of phosphorylationIDAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0042476OdontogenesisIGIbiological_process
GO:0042487Regulation of odontogenesis of dentin-containing toothIEAbiological_process
GO:0042733Embryonic digit morphogenesisIEAbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043401Steroid hormone mediated signaling pathwayIMPbiological_process
GO:0043407Negative regulation of MAP kinase activityIDAbiological_process
GO:0045603Positive regulation of endothelial cell differentiationIEAbiological_process
GO:0045662Negative regulation of myoblast differentiationIDAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIDAbiological_process
GO:0045778Positive regulation of ossificationIDAbiological_process
GO:0045786Negative regulation of cell cycleIDAbiological_process
GO:0045839Negative regulation of mitosisIDAbiological_process
GO:0045843Negative regulation of striated muscle tissue developmentIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0048286Lung alveolus developmentIDAbiological_process
GO:0048392Intermediate mesodermal cell differentiationIDAbiological_process
GO:0048660Regulation of smooth muscle cell proliferationIEAbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIDAbiological_process
GO:0048663Neuron fate commitmentIEAbiological_process
GO:0048701Embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0048745Smooth muscle tissue developmentISSbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeIDAbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIDAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0050918Positive chemotaxisIDAbiological_process
GO:0051150Regulation of smooth muscle cell differentiationIEAbiological_process
GO:0055020Positive regulation of cardiac muscle fiber developmentIMPbiological_process
GO:0060113Inner ear receptor cell differentiationIEAbiological_process
GO:0060197Cloacal septationIEAbiological_process
GO:0060235Lens induction in camera-type eyeIEAbiological_process
GO:0060272Embryonic skeletal joint morphogenesisIEAbiological_process
GO:0060363Cranial suture morphogenesisIEAbiological_process
GO:0060391Positive regulation of SMAD protein import into nucleusIDAbiological_process
GO:0060393Regulation of pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0060395SMAD protein signal transductionIDAbiological_process
GO:0060425Lung morphogenesisIDAbiological_process
GO:0060433Bronchus developmentIDAbiological_process
GO:0060438Trachea developmentIDAbiological_process
GO:0060440Trachea formationIEAbiological_process
GO:0060441Epithelial tube branching involved in lung morphogenesisIDAbiological_process
GO:0060442Branching involved in prostate gland morphogenesisIEAbiological_process
GO:0060449Bud elongation involved in lung branchingIEAbiological_process
GO:0060502Epithelial cell proliferation involved in lung morphogenesisIDAbiological_process
GO:0060503Bud dilation involved in lung branchingIDAbiological_process
GO:0060548Negative regulation of cell deathIDAbiological_process
GO:0060592Mammary gland formationIEAbiological_process
GO:0060684Epithelial-mesenchymal cell signalingIEAbiological_process
GO:0060686Negative regulation of prostatic bud formationIEAbiological_process
GO:0060687Regulation of branching involved in prostate gland morphogenesisIEAbiological_process
GO:0061036Positive regulation of cartilage developmentIDAbiological_process
GO:0061047Positive regulation of branching involved in lung morphogenesisIEA ISSbiological_process
GO:0061149BMP signaling pathway involved in ureter morphogenesisIEA ISSbiological_process
GO:0061151BMP signaling pathway involved in renal system segmentationIEA ISSbiological_process
GO:0061155Pulmonary artery endothelial tube morphogenesisIDAbiological_process
GO:0070244Negative regulation of thymocyte apoptotic processIMPbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0070700BMP receptor bindingIDAmolecular_function
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0071893BMP signaling pathway involved in nephric duct formationIDAbiological_process
GO:0072001Renal system developmentIEPbiological_process
GO:0072015Glomerular visceral epithelial cell developmentIEAbiological_process
GO:0072097Negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathwayIDAbiological_process
GO:0072101Specification of ureteric bud anterior/posterior symmetry by BMP signaling pathwayIDAbiological_process
GO:0072104Glomerular capillary formationIEA ISSbiological_process
GO:0072125Negative regulation of glomerular mesangial cell proliferationIDAbiological_process
GO:0072138Mesenchymal cell proliferation involved in ureteric bud developmentIEAbiological_process
GO:0072161Mesenchymal cell differentiation involved in kidney developmentIEAbiological_process
GO:0072192Ureter epithelial cell differentiationIEA ISSbiological_process
GO:0072193Ureter smooth muscle cell differentiationIEA ISSbiological_process
GO:0072198Mesenchymal cell proliferation involved in ureter developmentIEAbiological_process
GO:0072200Negative regulation of mesenchymal cell proliferation involved in ureter developmentIDAbiological_process
GO:0072205Metanephric collecting duct developmentIEA ISSbiological_process
GO:0090184Positive regulation of kidney developmentIDAbiological_process
GO:0090191Negative regulation of branching involved in ureteric bud morphogenesisIDAbiological_process
GO:0090194Negative regulation of glomerulus developmentIDAbiological_process
GO:2000005Negative regulation of metanephric S-shaped body morphogenesisIDAbiological_process
GO:2000007Negative regulation of metanephric comma-shaped body morphogenesisIDAbiological_process
GO:2000105Positive regulation of DNA-dependent DNA replicationIDAbiological_process
GO:2000137Negative regulation of cell proliferation involved in heart morphogenesisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16639663390.02043638540.80585849130.2763798665

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1282588768
GSE13712_SHEARDown-1.1480995826
GSE13712_STATICDown-1.2546308765
GSE19018Down-0.2126278387
GSE19899_A1Down-0.3878129194
GSE19899_A2Down-2.1295298645
PubMed_21979375_A1Down-0.1556149600
PubMed_21979375_A2Down-0.6839333346
GSE35957Up0.3982890014
GSE36640Up2.3125064298
GSE54402Down-1.1127619116
GSE9593Up0.0381412058
GSE43922Down-0.5252423951
GSE24585Up0.4786734426
GSE37065Up0.3041088488
GSE28863_A1Up0.5878748949
GSE28863_A2Up0.0528697791
GSE28863_A3Up0.3096889944
GSE28863_A4Up0.0794851101
GSE48662Down-0.1057179318

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21787378Furthermore, we observed that gremlin, an antagonist of BMP4, is secreted from ES cells and plays an important role in cellular senescence
19269967Adriamycin treatment resulted in the up-regulation of BMP4, which is underexpressed in NSCLC (non-small cell lung cancers)
19269967Overexpression of BMP4 was able to induce premature senescence in lung cancer cells and this process required the participation of cyclin/cyclin-dependent kinase (cdk) inhibitors p16(INK4a) and p21(WAF1/cip1)
19269967The present study provides useful clues to the evaluation of the potentiality of BMP4 as a responsive molecular target for cancer chemotherapy
19158083We demonstrate here that bone morphogenetic protein-4 is highly expressed in the retinal pigment epithelium and adjacent extracellular matrix of patients with dry age-related macular degeneration
19158083In vitro studies revealed that sublethal oxidative stress increased bone morphogenetic protein-4 expression in retinal pigment epithelial cells, and both bone morphogenetic protein-4 and persistent mild oxidative stress can induce retinal pigment epithelial cell senescence through p53-p21(Cip1/WAF1)-Rb pathway
19158083Oxidative stress-induced senescence can be blocked by Chordin-like, an antagonist of bone morphogenetic protein-4, or SB203580, a phospho-p38 inhibitor
19158083Our results suggest that oxidative stress and bone morphogenetic protein-4 may interact to promote retinal pigment epithelial cell senescence and that bone morphogenetic protein-4 may represent a novel therapeutic target to inhibit the progressive effects of oxidative stress and senescence in dry age-related macular degeneration
18258400CD9 antigen, MHC class I chain-related sequence A (MICA) and cell division cycle 37 homolog (CDC37) were up-regulated, and bone morphogenetic protein 4 (BMP4), dickkopf-1 (DKK1), and transcription factor 7-like 1 (TCF7L1) were down-regulated in old cells
12959928BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells
12959928We examined the effects of BMP4, another member of the TGF-beta superfamily, on specific oncogenic properties of A549 cancer cells
12959928When A549 cancer cells were treated continuously with 100 ng/ml of BMP4, a senescent phenotype was observed after 2 wk of treatment
12959928These studies suggest that BMP4 pathway signaling can induce senescence and thus negatively regulate the growth of A549 lung cancer cells
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