HCSGD entry for SLC1A4
1. General information
| Official gene symbol | SLC1A4 |
|---|---|
| Entrez ID | 6509 |
| Gene full name | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 |
| Other gene symbols | ASCT1 SATT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003333 | Amino acid transmembrane transport | IDA TAS | biological_process |
| GO:0005254 | Chloride channel activity | IDA | molecular_function |
| GO:0005882 | Intermediate filament | ISS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IC | cellular_component |
| GO:0006811 | Ion transport | TAS | biological_process |
| GO:0006821 | Chloride transport | IDA | biological_process |
| GO:0006865 | Amino acid transport | TAS | biological_process |
| GO:0006868 | Glutamine transport | TAS | biological_process |
| GO:0015180 | L-alanine transmembrane transporter activity | IDA | molecular_function |
| GO:0015184 | L-cystine transmembrane transporter activity | IDA | molecular_function |
| GO:0015186 | L-glutamine transmembrane transporter activity | TAS | molecular_function |
| GO:0015193 | L-proline transmembrane transporter activity | IDA | molecular_function |
| GO:0015194 | L-serine transmembrane transporter activity | IDA | molecular_function |
| GO:0015195 | L-threonine transmembrane transporter activity | IDA | molecular_function |
| GO:0015698 | Inorganic anion transport | IDA | biological_process |
| GO:0015808 | L-alanine transport | IDA | biological_process |
| GO:0015811 | L-cystine transport | IDA | biological_process |
| GO:0015824 | Proline transport | IDA | biological_process |
| GO:0015825 | L-serine transport | IDA | biological_process |
| GO:0015826 | Threonine transport | IDA | biological_process |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0017153 | Sodium:dicarboxylate symporter activity | IEA | molecular_function |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | IDA TAS | biological_process |
| GO:0034589 | Hydroxyproline transport | IDA | biological_process |
| GO:0034590 | L-hydroxyproline transmembrane transporter activity | IDA | molecular_function |
| GO:0035249 | Synaptic transmission, glutamatergic | NAS | biological_process |
| GO:0035524 | Proline transmembrane transport | IDA | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0050890 | Cognition | IMP | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:1902475 | L-alpha-amino acid transmembrane transport | IDA TAS | biological_process |
| GO:1902476 | Chloride transmembrane transport | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8661241898 | 0.0066482960 | 0.9999902473 | 0.1641603561 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4568274429 |
| GSE13712_SHEAR | Up | 0.0336573096 |
| GSE13712_STATIC | Down | -0.3122237366 |
| GSE19018 | Up | 0.2912167298 |
| GSE19899_A1 | Down | -0.3970531081 |
| GSE19899_A2 | Down | -2.1046884741 |
| PubMed_21979375_A1 | Down | -1.1620749163 |
| PubMed_21979375_A2 | Down | -1.3308518129 |
| GSE35957 | Down | -1.0122141747 |
| GSE36640 | Up | 0.0481610154 |
| GSE54402 | Down | -1.1433802866 |
| GSE9593 | Up | 0.4721473341 |
| GSE43922 | Down | -0.2651218284 |
| GSE24585 | Up | 0.6856278813 |
| GSE37065 | Down | -0.2205618563 |
| GSE28863_A1 | Up | 0.0507049806 |
| GSE28863_A2 | Up | 0.0562722081 |
| GSE28863_A3 | Down | -0.0754442281 |
| GSE28863_A4 | Down | -0.3051186120 |
| GSE48662 | Up | 0.0946552317 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Alanine | DB00160 | NUTR00013 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT001595 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017309 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022372 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024856 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026286 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039636 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042374 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
