HCSGD entry for ACD

1. General information

Official gene symbolACD
Entrez ID65057
Gene full nameadrenocortical dysplasia homolog (mouse)
Other gene symbolsPIP1 PTOP TINT1 TPP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000723Telomere maintenanceIDA TASbiological_process
GO:0000781Chromosome, telomeric regionIDA IEAcellular_component
GO:0000783Nuclear telomere cap complexIDAcellular_component
GO:0001501Skeletal system developmentIEAbiological_process
GO:0001655Urogenital system developmentIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005697Telomerase holoenzyme complexIEAcellular_component
GO:0006886Intracellular protein transportIMPbiological_process
GO:0007004Telomere maintenance via telomeraseIEAbiological_process
GO:0016233Telomere cappingIGI NASbiological_process
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0031848Protection from non-homologous end joining at telomereISSbiological_process
GO:0032202Telomere assemblyIMPbiological_process
GO:0032211Negative regulation of telomere maintenance via telomeraseIGI IMPbiological_process
GO:0035282SegmentationIEAbiological_process
GO:0042162Telomeric DNA bindingIEAmolecular_function
GO:0051973Positive regulation of telomerase activityIDA IEAbiological_process
GO:0060381Positive regulation of single-stranded telomeric DNA bindingIDAbiological_process
GO:0070182DNA polymerase bindingIPImolecular_function
GO:0070198Protein localization to chromosome, telomeric regionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88692756730.06274909390.99999024730.4727014596

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1952199794
GSE13712_SHEARDown-0.4977559177
GSE13712_STATICUp0.0953272493
GSE19018Up0.2254214449
GSE19899_A1Down-0.5254151152
GSE19899_A2Down-0.0316667278
PubMed_21979375_A1Up0.5830184114
PubMed_21979375_A2Down-0.3315864371
GSE35957Down-1.0457596887
GSE36640Down-1.3323374721
GSE54402Up0.1798023990
GSE9593Down-0.4938121366
GSE43922Down-0.0093174029
GSE24585Down-0.1379228735
GSE37065Down-0.2199671893
GSE28863_A1Down-0.0359075374
GSE28863_A2Up0.0621711845
GSE28863_A3Up0.1361626859
GSE28863_A4Down-0.0454652820
GSE48662Down-0.0270010098

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-24-3pMIMAT0000080MIRT030394MicroarrayFunctional MTI (Weak)19748357
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21527554SIRT1 silencing also caused telomere dysfunction-induced foci and nuclear abnormality that were clearly associated with reduced expressions of telomerase reverse transcriptase (TERT), and PTOP, which is a member of the shelter in complex
21527554Ectopic expression of either TERT or PTOP in SIRT1-depleted cells significantly restored cell proliferation
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