HCSGD entry for SKP2
1. General information
| Official gene symbol | SKP2 |
|---|---|
| Entrez ID | 6502 |
| Gene full name | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| Other gene symbols | FBL1 FBXL1 FLB1 p45 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000086 | G2/M transition of mitotic cell cycle | IEA | biological_process |
| GO:0000209 | Protein polyubiquitination | IEA | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | cellular_component |
| GO:0031145 | Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0033148 | Positive regulation of intracellular estrogen receptor signaling pathway | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0048661 | Positive regulation of smooth muscle cell proliferation | IEA | biological_process |
| GO:0051726 | Regulation of cell cycle | IEA | biological_process |
| GO:0071460 | Cellular response to cell-matrix adhesion | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9995218913 | 0.0000488887 | 0.9999902473 | 0.0114692982 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5519545332 |
| GSE13712_SHEAR | Down | -0.3216404148 |
| GSE13712_STATIC | Down | -0.1014226217 |
| GSE19018 | Down | -0.1072916927 |
| GSE19899_A1 | Down | -1.4367064395 |
| GSE19899_A2 | Down | -2.4050851159 |
| PubMed_21979375_A1 | Down | -1.9520600315 |
| PubMed_21979375_A2 | Down | -2.6513716699 |
| GSE35957 | Down | -0.0554978676 |
| GSE36640 | Down | -1.9098262740 |
| GSE54402 | Down | -1.2305077991 |
| GSE9593 | Down | -1.0240898538 |
| GSE43922 | Down | -1.1450417094 |
| GSE24585 | Down | -0.0664340711 |
| GSE37065 | Down | -0.8553823584 |
| GSE28863_A1 | Down | -0.6546009883 |
| GSE28863_A2 | Down | -0.7480620908 |
| GSE28863_A3 | Down | -1.0569837625 |
| GSE28863_A4 | Down | -0.0780375855 |
| GSE48662 | Down | -0.2733226295 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-142-3p | MIMAT0000434 | MIRT021626 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030943 | Microarray | Functional MTI (Weak) | 18591254 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 13 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25728679 | Mechanistically, Wnt7a induced cellular senescence via inactivation of S-phase kinase-associated protein 2, an important alternate regulator of cellular senescence |
| 25412315 | As an underlying molecular mechanism, we demonstrate that the loss of activity of signal transducer and activator of transcription 3 (STAT3) was specifically linked to the suppression of SKP2 expression |
| 25015320 | E3-ligase Skp2 predicts poor prognosis and maintains cancer stem cell pool in nasopharyngeal carcinoma |
| 25015320 | S-phase kinase associated protein 2 (Skp2) is overexpressed in several human cancers and associates with poor prognosis |
| 25015320 | In this study we found Skp2 was highly expressed in NPC specimen and correlated with poor prognosis |
| 25015320 | Knockdown of Skp2 partially reduced cell proliferation, promoted cellular senescence, and decreased the population of stem cell like aldehyde dehydrogenase1 positive cells as well as their self-renewal ability |
| 25015320 | Our study not only interprets the predictive role of Skp2 in the poor prognosis of NPC patients, but also reveals that Skp2 regulates the NPC cancer stem cell maintenance, which shed lights on the target therapy and early diagnosis of NPC in clinical application |
| 24464249 | Brain tumor senescence might be mediated by downregulation of S-phase kinase-associated protein 2 via butylidenephthalide leading to decreased cell viability |
| 24464249 | S-phase kinase-associated protein 2 (Skp2), a proto-oncogene, is generally upregulated in cancer |
| 24464249 | The downregulation of Skp2 is parallel with increasing p16 and p21 expression which causes G0/G1 arrest and tumor cell senescence |
| 24464249 | We also found that restoring the Skp2 protein level by exogenous overexpression prevents the BP-induced cell senescence |
| 24464249 | Therefore, the linkage between cell senescence and Skp2 expression is strengthened |
| 24464249 | In summary, these results emphasize that BP-triggered senescence in GBM cells is highly associated with its control on Skp2 regulation |
| 24077600 | S-phase kinase-associated protein 2 (Skp2) is an F box protein that plays critical roles in cell-cycle progression, senescence, metabolism, and acts as an Skp1-Cullin-1-F box (SCF) ubiquitin ligase substrate recognition factor |
| 24077600 | Overexpression of Skp2 is associated with poor prognosis and metastasis in many cancers and is a well validated drug target |
| 24077600 | This Skp2 inhibitor restricts cancer stemness and potentiates sensitivity to chemotherapeutic agents in multiple animal tumor models |
| 24077600 | These findings identify a new novel small molecule that targets the Skp2 and reduces tumor growth by attenuating aerobic glycolysis and inducing cellular senescence |
| 23911321 | Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression |
| 23911321 | Skp2 E3 ligase is overexpressed in numerous human cancers and plays a critical role in cell-cycle progression, senescence, metabolism, cancer progression, and metastasis |
| 23911321 | In the present study, we identified a specific Skp2 inhibitor using high-throughput in silico screening of large and diverse chemical libraries |
| 23911321 | This Skp2 inhibitor selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes |
| 23911321 | It also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival and Akt-mediated glycolysis and triggering p53-independent cellular senescence |
| 23911321 | Strikingly, we discovered a critical function of Skp2 in positively regulating cancer stem cell populations and self-renewal ability through genetic and pharmacological approaches |
| 23911321 | Notably, Skp2 inhibitor exhibits potent antitumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival |
| 23911321 | Our study thus provides pharmacological evidence that Skp2 is a promising target for restricting cancer stem cell and cancer progression |
| 23254306 | Lowering the threshold of cellular senescence, the process employed by cells to thwart abnormal cell proliferation, though inhibition of CDK2 or Skp2 (regulator of CDK inhibitors) has been recently suggested as a potential avenue for cancer treatment |
| 22937180 | The ubiquitin-ligase Skp2 negatively regulates p27(Kip1) and, during TIS, is translocated to the cytoplasm before its expression is decreased in senescent cells |
| 22937180 | Overexpression of Skp2 blocks the effects of AZQ on senescence and p27(Kip1) induction |
| 22937180 | We also find that stable long-term short hairpin RNA knockdown of Skp2 decreases proliferation but does not generate the complete senescence phenotype |
| 22937180 | We conclude that Skp2 participates in regulating TIS but, alone, is insufficient to induce senescence in cancer cells |
| 22200179 | Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis |
| 22200179 | S-phase kinase-associated protein 2 (Skp2) belongs to the F-box protein family |
| 22200179 | Skp2 has also been demonstrated to display an oncogenic function since its overexpression has been observed in many human cancers |
| 22200179 | This review discusses the recent discoveries on the novel roles of Skp2 in regulating cellular senescence, cancer progression, and metastasis, as well as the therapeutic potential of targeting Skp2 for human cancer treatment |
| 21677876 | Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2 |
| 21677876 | The induction of the senescence-associated secretory phenotype by androgen depletion was mediated, at least in part, by down-regulation of S-phase kinase-associated protein 2, whereas the neuroendocrine differentiation of prostate cancer cells was under separate control |
| 21677876 | These data demonstrate a previously unrecognized link between inhibition of androgen receptor signaling, down-regulation of S-phase kinase-associated protein 2, and the appearance of secretory, tumor-promoting senescent cells in prostate tumors |
| 20237562 | Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence |
| 20237562 | Here we show that although Skp2 inactivation on its own does not induce cellular senescence, aberrant proto-oncogenic signals as well as inactivation of tumour suppressor genes do trigger a potent, tumour-suppressive senescence response in mice and cells devoid of Skp2 |
| 20237562 | We further demonstrate that genetic Skp2 inactivation evokes cellular senescence even in oncogenic conditions in which the p19(Arf)-p53 response is impaired, whereas a Skp2-SCF complex inhibitor can trigger cellular senescence in p53/Pten-deficient cells and tumour regression in preclinical studies |
| 20237562 | Our findings therefore provide proof-of-principle evidence that pharmacological inhibition of Skp2 may represent a general approach for cancer prevention and therapy |
| 19235838 | FoxM1 depletion led to the down-regulation of its target genes c-MYC and Skp2, coupled with the accumulation of the CDK inhibitor p27(kip1) |
| 11738146 | Whereas, the Skp1 component of the SCF complex is overexpressed in senescent fibroblasts, the abundance of the F-box protein Skp2 is strongly reduced |
Entries Per Page
Displaying Page of
