HCSGD entry for SKP1

1. General information

Official gene symbolSKP1
Entrez ID6500
Gene full nameS-phase kinase-associated protein 1
Other gene symbolsEMC19 OCP-II OCP2 SKP1A TCEB1L p19A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006511Ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0019005SCF ubiquitin ligase complexIDAcellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0031467Cul7-RING ubiquitin ligase complexIDAcellular_component
GO:0031519PcG protein complexIDAcellular_component
GO:0035518Histone H2A monoubiquitinationIDAbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.44981946730.55698252730.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1687842463
GSE13712_SHEARDown-0.0341631851
GSE13712_STATICDown-0.0388402035
GSE19018Up0.1678830616
GSE19899_A1Up0.1223381412
GSE19899_A2Up0.1634689817
PubMed_21979375_A1Down-0.1346775636
PubMed_21979375_A2Down-0.0350269489
GSE35957Up0.2332562937
GSE36640Up0.3598648128
GSE54402Down-0.0832408543
GSE9593Up0.1003136520
GSE43922Down-0.0957859543
GSE24585Up0.0215129193
GSE37065Up0.0360590040
GSE28863_A1Up0.2259273493
GSE28863_A2Up0.5880854408
GSE28863_A3Down-0.8143317791
GSE28863_A4Down-0.2985785633
GSE48662Down-0.1242716110

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Naphthalen-1-Yl-Acetic AcidDB01750 EXPT02353
(2S)-2-(1H-indol-3-yl)hexanoic acidDB06980 -
(2S)-2-(1H-indol-3-yl)pentanoic acidDB06981 -
(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acidDB06982 -
1H-INDOL-3-YLACETIC ACIDDB07950 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1301-3pMIMAT0005797MIRT035977CLASHFunctional MTI (Weak)23622248
hsa-miR-151a-5pMIMAT0004697MIRT038197CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

11738146Whereas, the Skp1 component of the SCF complex is overexpressed in senescent fibroblasts, the abundance of the F-box protein Skp2 is strongly reduced
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