HCSGD entry for SKIL

1. General information

Official gene symbolSKIL
Entrez ID6498
Gene full nameSKI-like oncogene
Other gene symbolsSNO SnoA SnoI SnoN
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IEA TASbiological_process
GO:0000166Nucleotide bindingIEAmolecular_function
GO:0001669Acrosomal vesicleIEAcellular_component
GO:0001825Blastocyst formationIEAbiological_process
GO:0002260Lymphocyte homeostasisIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003682Chromatin bindingIEA ISSmolecular_function
GO:0003714Transcription corepressor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007050Cell cycle arrestIEA ISSbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIEA TASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007519Skeletal muscle tissue developmentIDAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016605PML bodyIDAcellular_component
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayIDA IEAbiological_process
GO:0032403Protein complex bindingIDAmolecular_function
GO:0034097Response to cytokineIEAbiological_process
GO:0042981Regulation of apoptotic processIBA ISSbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0045596Negative regulation of cell differentiationIEA ISSbiological_process
GO:0046332SMAD bindingIEA IPImolecular_function
GO:0046677Response to antibioticIEPbiological_process
GO:0050772Positive regulation of axonogenesisIEA IMPbiological_process
GO:0070207Protein homotrimerizationIDAbiological_process
GO:0070208Protein heterotrimerizationIDAbiological_process
GO:0070306Lens fiber cell differentiationIEAbiological_process
GO:0070848Response to growth factorIDAbiological_process
GO:1902043Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
GO:1902231Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damageIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06564402950.02787112190.55201805110.3175419299

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5597405716
GSE13712_SHEARUp0.3130673026
GSE13712_STATICUp0.3041386378
GSE19018Down-0.6330104995
GSE19899_A1Up0.3371909394
GSE19899_A2Up0.0947646426
PubMed_21979375_A1Up0.7135133300
PubMed_21979375_A2Up0.2768539078
GSE35957Up0.3847265224
GSE36640Up0.2147471099
GSE54402Up0.6090612620
GSE9593Down-0.1836147896
GSE43922Up0.4744741110
GSE24585Up0.5226045895
GSE37065Up0.2012379227
GSE28863_A1Down-1.0213353886
GSE28863_A2Down-0.9346442055
GSE28863_A3Down-1.0695733464
GSE28863_A4Down-0.5896654590
GSE48662Up0.2327849595

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022626MicroarrayFunctional MTI (Weak)18668037
hsa-miR-26b-5pMIMAT0000083MIRT029466MicroarrayFunctional MTI (Weak)19088304
hsa-miR-30b-5pMIMAT0000420MIRT046162CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.