HCSGD entry for SIM2
1. General information
| Official gene symbol | SIM2 |
|---|---|
| Entrez ID | 6493 |
| Gene full name | single-minded homolog 2 (Drosophila) |
| Other gene symbols | HMC13F06 HMC29C01 SIM bHLHe15 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007399 | Nervous system development | IEA | biological_process |
| GO:0009880 | Embryonic pattern specification | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8855829604 | 0.1428220166 | 0.9999902473 | 0.7281073601 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0382300912 |
| GSE13712_SHEAR | Up | 0.0481935313 |
| GSE13712_STATIC | Up | 0.1190269991 |
| GSE19018 | Down | -0.5361336846 |
| GSE19899_A1 | Down | -0.0246131145 |
| GSE19899_A2 | Up | 0.0810740369 |
| PubMed_21979375_A1 | Down | -0.1040547316 |
| PubMed_21979375_A2 | Up | 0.2056056943 |
| GSE35957 | Up | 0.0338232864 |
| GSE36640 | Down | -1.2096217062 |
| GSE54402 | Down | -0.2632005612 |
| GSE9593 | Down | -0.0150714169 |
| GSE43922 | Up | 0.1884937760 |
| GSE24585 | Down | -0.6284788712 |
| GSE37065 | Down | -0.0866337794 |
| GSE28863_A1 | Down | -0.0901671983 |
| GSE28863_A2 | Down | -0.1871262311 |
| GSE28863_A3 | Up | 0.2306794296 |
| GSE28863_A4 | Up | 0.0708604069 |
| GSE48662 | Down | -0.0567475025 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20501696 | Here, we show that MORC3 colocalizes with PML by a two-step molecular mechanism: the PML-independent formation of MORC3 NDs by the ATPase cycle, and the association of MORC3 with PML via the SUMO1-SUMO-interacting motif (SIM) |
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