HCSGD entry for PMEL
1. General information
| Official gene symbol | PMEL |
|---|---|
| Entrez ID | 6490 |
| Gene full name | premelanosome protein |
| Other gene symbols | D12S53E ME20 ME20-M ME20M P1 P100 PMEL17 SI SIL SILV gp100 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0032438 | Melanosome organization | IDA | biological_process |
| GO:0032585 | Multivesicular body membrane | IDA | cellular_component |
| GO:0042438 | Melanin biosynthetic process | IEA | biological_process |
| GO:0042470 | Melanosome | IDA IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4539954333 | 0.4191952737 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1182115353 |
| GSE13712_SHEAR | Down | -0.0303630066 |
| GSE13712_STATIC | Up | 0.1357737945 |
| GSE19018 | Up | 0.0408427073 |
| GSE19899_A1 | Down | -0.0579169286 |
| GSE19899_A2 | Up | 0.2565840154 |
| PubMed_21979375_A1 | Down | -0.4080526468 |
| PubMed_21979375_A2 | Down | -0.2642025983 |
| GSE35957 | Up | 0.1828266051 |
| GSE36640 | Down | -0.7324743349 |
| GSE54402 | Up | 0.0088374012 |
| GSE9593 | Down | -0.0994284565 |
| GSE43922 | Up | 0.0193407908 |
| GSE24585 | Up | 1.6567337600 |
| GSE37065 | Up | 0.0727394511 |
| GSE28863_A1 | Down | -0.1159703068 |
| GSE28863_A2 | Down | -0.0513424924 |
| GSE28863_A3 | Up | 0.1656567493 |
| GSE28863_A4 | Down | -0.0198372098 |
| GSE48662 | Down | -0.1107054089 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017320 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
