HCSGD entry for DCLRE1B
1. General information
| Official gene symbol | DCLRE1B |
|---|---|
| Entrez ID | 64858 |
| Gene full name | DNA cross-link repair 1B |
| Other gene symbols | APOLLO SNM1B SNMIB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000075 | Cell cycle checkpoint | IMP | biological_process |
| GO:0000723 | Telomere maintenance | IMP | biological_process |
| GO:0000781 | Chromosome, telomeric region | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0008409 | 5'-3' exonuclease activity | IDA | molecular_function |
| GO:0031627 | Telomeric loop formation | ISS | biological_process |
| GO:0031848 | Protection from non-homologous end joining at telomere | IMP | biological_process |
| GO:0031860 | Telomeric 3' overhang formation | ISS | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9774542913 | 0.0028292694 | 0.9999902473 | 0.1062827389 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0056293519 |
| GSE13712_SHEAR | Down | -0.3790766352 |
| GSE13712_STATIC | Down | -0.1426908250 |
| GSE19018 | Down | -0.4067577803 |
| GSE19899_A1 | Down | -0.4100404426 |
| GSE19899_A2 | Down | -1.9143812225 |
| PubMed_21979375_A1 | Down | -0.4990770595 |
| PubMed_21979375_A2 | Down | -1.5590123341 |
| GSE35957 | Down | -1.1251101340 |
| GSE36640 | Down | -2.7661937295 |
| GSE54402 | Up | 0.0872159318 |
| GSE9593 | Down | -0.5288087152 |
| GSE43922 | Down | -0.2559483722 |
| GSE24585 | Down | -0.1419065273 |
| GSE37065 | Down | -0.1228410049 |
| GSE28863_A1 | Down | -0.0657786944 |
| GSE28863_A2 | Up | 0.8289074080 |
| GSE28863_A3 | Up | 0.0873498634 |
| GSE28863_A4 | Down | -0.3140374411 |
| GSE48662 | Down | -0.6584828237 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-331-3p | MIMAT0000760 | MIRT019240 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT019658 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-320b | MIMAT0005792 | MIRT036181 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041758 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044451 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20479256 | Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson syndrome |
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