HCSGD entry for PLEKHG2
1. General information
| Official gene symbol | PLEKHG2 |
|---|---|
| Entrez ID | 64857 |
| Gene full name | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 |
| Other gene symbols | ARHGEF42 CLG |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9808982827 | 0.0559576802 | 0.9999902473 | 0.4446561388 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1885990385 |
| GSE13712_SHEAR | Down | -0.1942123575 |
| GSE13712_STATIC | Down | -0.0003330008 |
| GSE19018 | Down | -0.1254289243 |
| GSE19899_A1 | Down | -0.3141906564 |
| GSE19899_A2 | Down | -0.5764494469 |
| PubMed_21979375_A1 | Down | -0.1148835531 |
| PubMed_21979375_A2 | Down | -0.1091245156 |
| GSE35957 | Down | -0.3702121518 |
| GSE36640 | Down | -0.0800563354 |
| GSE54402 | Down | -0.0876377858 |
| GSE9593 | Down | -0.3313550149 |
| GSE43922 | Down | -0.3904692806 |
| GSE24585 | Up | 0.0104975804 |
| GSE37065 | Down | -0.3794422471 |
| GSE28863_A1 | Up | 0.1506800030 |
| GSE28863_A2 | Down | -0.1299450743 |
| GSE28863_A3 | Up | 0.1240304748 |
| GSE28863_A4 | Down | -0.0692568075 |
| GSE48662 | Up | 0.0413698437 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002749 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026245 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037583 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042993 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048117 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
