HCSGD entry for ST3GAL4
1. General information
| Official gene symbol | ST3GAL4 |
|---|---|
| Entrez ID | 6484 |
| Gene full name | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 |
| Other gene symbols | CGS23 NANTA3 SAT3 SIAT4 SIAT4C ST3GalIV STZ |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0003836 | Beta-galactoside (CMP) alpha-2,3-sialyltransferase activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006486 | Protein glycosylation | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016266 | O-glycan processing | TAS | biological_process |
| GO:0018146 | Keratan sulfate biosynthetic process | TAS | biological_process |
| GO:0018279 | Protein N-linked glycosylation via asparagine | TAS | biological_process |
| GO:0030173 | Integral component of Golgi membrane | IEA | cellular_component |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0032580 | Golgi cisterna membrane | IEA | cellular_component |
| GO:0042339 | Keratan sulfate metabolic process | TAS | biological_process |
| GO:0043687 | Post-translational protein modification | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047288 | Monosialoganglioside sialyltransferase activity | IEA | molecular_function |
| GO:0097503 | Sialylation | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8655947798 | 0.3830679609 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0646971313 |
| GSE13712_SHEAR | Down | -0.6027312959 |
| GSE13712_STATIC | Up | 0.1652900872 |
| GSE19018 | Up | 0.1341608901 |
| GSE19899_A1 | Down | -0.2582514619 |
| GSE19899_A2 | Up | 0.0435860588 |
| PubMed_21979375_A1 | Down | -0.2366731179 |
| PubMed_21979375_A2 | Down | -0.2147400202 |
| GSE35957 | Down | -0.0090760553 |
| GSE36640 | Down | -0.0852811137 |
| GSE54402 | Up | 0.0037492558 |
| GSE9593 | Up | 0.0460211256 |
| GSE43922 | Up | 0.0568323927 |
| GSE24585 | Down | -0.3309826853 |
| GSE37065 | Up | 0.1090320640 |
| GSE28863_A1 | Up | 0.0388116800 |
| GSE28863_A2 | Up | 0.0483709936 |
| GSE28863_A3 | Down | -0.0161186631 |
| GSE28863_A4 | Up | 0.0607037537 |
| GSE48662 | Down | -0.0801818227 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24996978 | METHODS: Non-diabetic and streptozotocin (STZ, 10mgkg(-1)day(-1) for 7days, i |
| 24996978 | Administration of insulin at doses that maintained normoglycemia or mild hypoglycemia suppressed the changes induced by STZ |
| 16731828 | Induction of senescent endothelial cells in aortas and elevation of plasma PAI-1 levels were observed in streptozotocin (STZ) diabetic mice, whereas these changes induced by STZ were attenuated in ASK1-knockout mice |
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