HCSGD entry for P2RY12
1. General information
| Official gene symbol | P2RY12 |
|---|---|
| Entrez ID | 64805 |
| Gene full name | purinergic receptor P2Y, G-protein coupled, 12 |
| Other gene symbols | ADPG-R BDPLT8 HORK3 P2T(AC) P2Y(12)R P2Y(AC) P2Y(ADP) P2Y(cyc) P2Y12 SP1999 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001609 | G-protein coupled adenosine receptor activity | IEA | molecular_function |
| GO:0001621 | ADP receptor activity | IEA | molecular_function |
| GO:0005085 | Guanyl-nucleotide exchange factor activity | TAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005901 | Caveola | IEA | cellular_component |
| GO:0007188 | Adenylate cyclase-modulating G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0007599 | Hemostasis | NAS | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0009925 | Basal plasma membrane | IEA | cellular_component |
| GO:0010700 | Negative regulation of norepinephrine secretion | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030030 | Cell projection organization | IEA | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0043087 | Regulation of GTPase activity | TAS | biological_process |
| GO:0043270 | Positive regulation of ion transport | IEA | biological_process |
| GO:0043491 | Protein kinase B signaling | IEA | biological_process |
| GO:0045596 | Negative regulation of cell differentiation | IEA | biological_process |
| GO:0051924 | Regulation of calcium ion transport | IEA | biological_process |
| GO:0070527 | Platelet aggregation | IEA | biological_process |
| GO:0070588 | Calcium ion transmembrane transport | IEA | biological_process |
| GO:0071805 | Potassium ion transmembrane transport | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3948920064 | 0.9470984765 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0747073983 |
| GSE13712_SHEAR | Down | -0.0196632119 |
| GSE13712_STATIC | Up | 0.1465821948 |
| GSE19018 | Up | 0.1319160321 |
| GSE19899_A1 | Up | 0.0751088446 |
| GSE19899_A2 | Up | 0.1521271416 |
| PubMed_21979375_A1 | Down | -0.0283379793 |
| PubMed_21979375_A2 | Up | 0.1778544788 |
| GSE35957 | Down | -0.0008729584 |
| GSE36640 | Up | 0.0801756984 |
| GSE54402 | Up | 0.0282561168 |
| GSE9593 | Down | -0.0697871222 |
| GSE43922 | Up | 0.0087191115 |
| GSE24585 | Up | 0.2513507929 |
| GSE37065 | Down | -0.0154859965 |
| GSE28863_A1 | Up | 0.3779858737 |
| GSE28863_A2 | Up | 0.2621239350 |
| GSE28863_A3 | Up | 0.0568795716 |
| GSE28863_A4 | Down | -0.0566054299 |
| GSE48662 | Down | -0.0402270436 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Ticlopidine | DB00208 | APRD01257 |
| Clopidogrel | DB00758 | APRD00444 |
| Epoprostenol | DB01240 | APRD00949 |
| AZD6140 | DB04902 | - |
| Prasugrel | DB06209 | - |
| Cangrelor | DB06441 | - |
| Ticagrelor | DB08816 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17982416 | The P2Y receptor agonists listed above induced a concentration-dependent rise in intracellular calcium in the TM cells |
| 17982416 | Cells at passage 18 showed significantly lower levels of intracellular calcium induced by ATP (36%), UTP (34%), and ADP (52%) compared to cells at passage 2, independent from any changes in P2Y receptor changes in expression |
| 17982416 | CONCLUSIONS: The ability to release ATP in response to mechanical stress and the presence of functional P2Y receptors in TM cells suggest a novel mechanism by which TM cells could sense and respond to changes in intraocular pressure (IOP) |
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