HCSGD entry for NMNAT1
1. General information
| Official gene symbol | NMNAT1 |
|---|---|
| Entrez ID | 64802 |
| Gene full name | nicotinamide nucleotide adenylyltransferase 1 |
| Other gene symbols | LCA9 NMNAT PNAT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000309 | Nicotinamide-nucleotide adenylyltransferase activity | IDA TAS | molecular_function |
| GO:0004515 | Nicotinate-nucleotide adenylyltransferase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0009435 | NAD biosynthetic process | IC IEA | biological_process |
| GO:0016779 | Nucleotidyltransferase activity | IEA | molecular_function |
| GO:0019674 | NAD metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5573598306 | 0.1747810759 | 0.9999902473 | 0.8091689995 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1330165858 |
| GSE13712_SHEAR | Down | -0.4809577534 |
| GSE13712_STATIC | Down | -0.1267962470 |
| GSE19018 | Up | 0.1267946885 |
| GSE19899_A1 | Down | -0.0074706294 |
| GSE19899_A2 | Up | 0.1332885123 |
| PubMed_21979375_A1 | Up | 0.2712109281 |
| PubMed_21979375_A2 | Down | -0.5137150374 |
| GSE35957 | Up | 0.0248197288 |
| GSE36640 | Up | 0.6589308676 |
| GSE54402 | Up | 0.0261097995 |
| GSE9593 | Up | 0.1885402509 |
| GSE43922 | Up | 0.0361263679 |
| GSE24585 | Up | 0.4827455970 |
| GSE37065 | Down | -0.2230236730 |
| GSE28863_A1 | Down | -0.4611761729 |
| GSE28863_A2 | Down | -0.4643159578 |
| GSE28863_A3 | Down | -0.4413789526 |
| GSE28863_A4 | Down | -0.1350044840 |
| GSE48662 | Up | 0.1665991142 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Nicotinamide Mononucleotide | DB03227 | EXPT02366 |
| Deamido-Nad+ | DB04099 | EXPT01234 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022393 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20457531 | Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the formation of nicotinamide adenine dinucleotide (NAD) |
| 20457531 | In humans, three isozymes have been identified: NMNAT1, which is widely expressed in all tissues, NMNAT2 and NMNAT3, which show a tissue-specific expression and whose mRNA levels are generally lower compared to NMNAT1 |
| 20457531 | In the present study we determined the individual NMNAT isozymes activity in human red blood cells (RBCs) by using a biochemical discrimination assay based on the distinctive catalytic properties of the three proteins |
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