HCSGD entry for AEN
1. General information
| Official gene symbol | AEN |
|---|---|
| Entrez ID | 64782 |
| Gene full name | apoptosis enhancing nuclease |
| Other gene symbols | ISG20L1 pp12744 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0004527 | Exonuclease activity | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0008152 | Metabolic process | IDA | biological_process |
| GO:0010212 | Response to ionizing radiation | IDA | biological_process |
| GO:0042771 | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IDA | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1734226359 | 0.4647534858 | 0.8177458259 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0672943248 |
| GSE13712_SHEAR | Down | -0.0795590277 |
| GSE13712_STATIC | Up | 0.3377026094 |
| GSE19018 | Down | -0.4853963877 |
| GSE19899_A1 | Down | -0.0236974322 |
| GSE19899_A2 | Up | 0.3323427130 |
| PubMed_21979375_A1 | Up | 0.9352149692 |
| PubMed_21979375_A2 | Up | 0.7356928070 |
| GSE35957 | Down | -0.0936811170 |
| GSE36640 | Down | -0.2502602753 |
| GSE54402 | Up | 0.3497052352 |
| GSE9593 | Down | -0.1757515810 |
| GSE43922 | Up | 0.1096883235 |
| GSE24585 | Down | -0.1890454749 |
| GSE37065 | Up | 0.3102422858 |
| GSE28863_A1 | Down | -0.0875776140 |
| GSE28863_A2 | Down | -0.3895316674 |
| GSE28863_A3 | Down | -0.0988236850 |
| GSE28863_A4 | Up | 0.2253680494 |
| GSE48662 | Up | 0.1080409243 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT021177 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029335 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-193b-5p | MIMAT0004767 | MIRT038005 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
