HCSGD entry for CERK
1. General information
| Official gene symbol | CERK |
|---|---|
| Entrez ID | 64781 |
| Gene full name | ceramide kinase |
| Other gene symbols | LK4 dA59H18.2 dA59H18.3 hCERK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0001729 | Ceramide kinase activity | IDA | molecular_function |
| GO:0003951 | NAD+ kinase activity | IEA | molecular_function |
| GO:0004143 | Diacylglycerol kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0006672 | Ceramide metabolic process | IDA TAS | biological_process |
| GO:0006687 | Glycosphingolipid metabolic process | TAS | biological_process |
| GO:0007205 | Protein kinase C-activating G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IDA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046834 | Lipid phosphorylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1163659473 | 0.2908199650 | 0.7001690237 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6040285879 |
| GSE13712_SHEAR | Down | -1.0492708646 |
| GSE13712_STATIC | Down | -0.5992721661 |
| GSE19018 | Up | 0.0854215933 |
| GSE19899_A1 | Down | -0.0624378730 |
| GSE19899_A2 | Up | 0.1108728917 |
| PubMed_21979375_A1 | Down | -0.4161376248 |
| PubMed_21979375_A2 | Up | 0.8691143735 |
| GSE35957 | Up | 0.6680038180 |
| GSE36640 | Down | -0.2626265229 |
| GSE54402 | Up | 0.8129432823 |
| GSE9593 | Down | -0.0361685278 |
| GSE43922 | Up | 0.0814788805 |
| GSE24585 | Down | -0.3853209971 |
| GSE37065 | Down | -0.3370132246 |
| GSE28863_A1 | Up | 0.4870163338 |
| GSE28863_A2 | Up | 0.2150565307 |
| GSE28863_A3 | Down | -0.0575397289 |
| GSE28863_A4 | Up | 0.0119344712 |
| GSE48662 | Up | 0.0014310236 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-128-3p | MIMAT0000424 | MIRT022006 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027241 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029316 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040252 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
