HCSGD entry for MICAL1
1. General information
| Official gene symbol | MICAL1 |
|---|---|
| Entrez ID | 64780 |
| Gene full name | microtubule associated monooxygenase, calponin and LIM domain containing 1 |
| Other gene symbols | MICAL MICAL-1 NICAL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001933 | Negative regulation of protein phosphorylation | IEA | biological_process |
| GO:0003779 | Actin binding | IDA | molecular_function |
| GO:0004497 | Monooxygenase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005882 | Intermediate filament | NAS | cellular_component |
| GO:0007010 | Cytoskeleton organization | NAS | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016709 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | IDA | molecular_function |
| GO:0017124 | SH3 domain binding | IPI | molecular_function |
| GO:0017137 | Rab GTPase binding | IEA | molecular_function |
| GO:0019417 | Sulfur oxidation | IEA ISS | biological_process |
| GO:0030042 | Actin filament depolymerization | IDA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IEA | biological_process |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
| GO:0071949 | FAD binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7250953117 | 0.0750228525 | 0.9999902473 | 0.5167957341 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1117134623 |
| GSE13712_SHEAR | Down | -0.6828371624 |
| GSE13712_STATIC | Down | -0.6086215480 |
| GSE19018 | Down | -0.0458205909 |
| GSE19899_A1 | Up | 0.0654847673 |
| GSE19899_A2 | Down | -0.1977532856 |
| PubMed_21979375_A1 | Up | 1.0764596282 |
| PubMed_21979375_A2 | Up | 0.7631043015 |
| GSE35957 | Down | -0.9203233823 |
| GSE36640 | Down | -0.5526326113 |
| GSE54402 | Up | 0.2448042502 |
| GSE9593 | Down | -1.0397771710 |
| GSE43922 | Up | 0.0464702736 |
| GSE24585 | Up | 0.2052197165 |
| GSE37065 | Down | -0.1480600824 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2194112177 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023104 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045642 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
