HCSGD entry for SMURF2
1. General information
| Official gene symbol | SMURF2 |
|---|---|
| Entrez ID | 64750 |
| Gene full name | SMAD specific E3 ubiquitin protein ligase 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0000151 | Ubiquitin ligase complex | IDA | cellular_component |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA IEA TAS | molecular_function |
| GO:0005160 | Transforming growth factor beta receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IBA NAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | IBA TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0017015 | Regulation of transforming growth factor beta receptor signaling pathway | NAS | biological_process |
| GO:0030509 | BMP signaling pathway | TAS | biological_process |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0030579 | Ubiquitin-dependent SMAD protein catabolic process | IDA | biological_process |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0045121 | Membrane raft | IEA | cellular_component |
| GO:0045892 | Negative regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0046332 | SMAD binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0125993389 | 0.5708851905 | 0.2806698816 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1091020942 |
| GSE13712_SHEAR | Up | 0.8897395565 |
| GSE13712_STATIC | Up | 0.8621920467 |
| GSE19018 | Up | 0.2829274903 |
| GSE19899_A1 | Up | 0.0039927148 |
| GSE19899_A2 | Up | 0.2117391893 |
| PubMed_21979375_A1 | Down | -1.1987153547 |
| PubMed_21979375_A2 | Down | -0.5677612993 |
| GSE35957 | Up | 0.8790671176 |
| GSE36640 | Up | 0.8631425417 |
| GSE54402 | Down | -0.3755924106 |
| GSE9593 | Up | 0.6194831905 |
| GSE43922 | Down | -0.0850498809 |
| GSE24585 | Up | 0.7503252311 |
| GSE37065 | Down | -0.1101148285 |
| GSE28863_A1 | Down | -0.1495047386 |
| GSE28863_A2 | Up | 0.6291018890 |
| GSE28863_A3 | Down | -0.2470626557 |
| GSE28863_A4 | Up | 0.3486023058 |
| GSE48662 | Up | 0.2715817056 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023400 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031987 | Microarray | Functional MTI (Weak) | 21199864 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26166038 | Subsequent studies showed that SMURF2 was downregulated in pancreatic cancer tissues and it promoted mesenchymal-epithelial transition (MET) in pancreatic cancer cells as well as its expression negatively associated with gemcitabine-resistance, but it did not alter cell viability, cell cycle and cell senescence |
| 24478790 | These two loci harbor a number of novel candidate genes with SNPs, and our gene-wise association analysis identified multiple genes, including DCAF7, POLG2, CEP95, and SMURF2 at 17q23 |
| 24478790 | Among these genes, multiple SNPs were associated with leukocyte telomere length, but the strongest association was observed with one contiguous haplotype in CEP95 and SMURF2 |
| 21933340 | Here, we report for the first time the identification of Smurf2 as the E3 ligase that ubiquitinates Id1 and Id3 |
| 21933340 | Furthermore, we found that Id1 is the mediator through which Smurf2 regulates p16 expression, providing a mechanistic link between Smurf2 and p16 expression during senescence |
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