HCSGD entry for SHMT2


1. General information

Official gene symbolSHMT2
Entrez ID6472
Gene full nameserine hydroxymethyltransferase 2 (mitochondrial)
Other gene symbolsGLYA SHMT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003682Chromatin bindingIDAmolecular_function
GO:0004372Glycine hydroxymethyltransferase activityIDA IEAmolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005743Mitochondrial inner membraneIDA IEAcellular_component
GO:0005758Mitochondrial intermembrane spaceIEAcellular_component
GO:0005759Mitochondrial matrixIDA IEAcellular_component
GO:0006544Glycine metabolic processIEAbiological_process
GO:0006563L-serine metabolic processIEAbiological_process
GO:0006564L-serine biosynthetic processIEAbiological_process
GO:0006730One-carbon metabolic processIDAbiological_process
GO:0008168Methyltransferase activityIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008732L-allo-threonine aldolase activityIEAmolecular_function
GO:0015630Microtubule cytoskeletonIDAcellular_component
GO:0016597Amino acid bindingIEAmolecular_function
GO:0019264Glycine biosynthetic process from serineIEAbiological_process
GO:0030170Pyridoxal phosphate bindingIEAmolecular_function
GO:0035999Tetrahydrofolate interconversionIEAbiological_process
GO:0042645Mitochondrial nucleoidIDAcellular_component
GO:0042802Identical protein bindingIEAmolecular_function
GO:0051289Protein homotetramerizationIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87447550250.01645902510.99999024730.2501109059

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5419045644
GSE13712_SHEARUp0.0907987865
GSE13712_STATICDown-0.0836798556
GSE19018Up0.6266052820
GSE19899_A1Down-0.0646143160
GSE19899_A2Down-0.3116118922
PubMed_21979375_A1Up0.1284021163
PubMed_21979375_A2Down-0.7447447301
GSE35957Down-0.7251731824
GSE36640Down-0.8250384174
GSE54402Down-0.1839772942
GSE9593Down-0.2002436996
GSE43922Down-0.0137222649
GSE24585Down-0.6208272636
GSE37065Down-0.4179180200
GSE28863_A1Up0.2804103987
GSE28863_A2Down-0.5896844482
GSE28863_A3Down-0.1761081255
GSE28863_A4Up0.0116113030
GSE48662Up0.2694294961

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Tetrahydrofolic acidDB00116 NUTR00056
GlycineDB00145 NUTR00028

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT006985Luciferase reporter assay//Reporter assay;ProteomicsFunctional MTI21512034
hsa-miR-193b-3pMIMAT0002819MIRT006985MicroarrayFunctional MTI (Weak)20304954
hsa-miR-193b-3pMIMAT0002819MIRT006985CLASHFunctional MTI (Weak)23622248
hsa-miR-124-3pMIMAT0000422MIRT022849Proteomics;MicroarrayNon-Functional MTI (Weak)18668037
hsa-miR-940MIMAT0004983MIRT036608CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040137CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042617CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045122CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049169CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052431CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.