HCSGD entry for SHH

1. General information

Official gene symbolSHH
Entrez ID6469
Gene full namesonic hedgehog
Other gene symbolsHHG1 HLP3 HPE3 MCOPCB5 SMMCI TPT TPTPS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0001569Patterning of blood vesselsISSbiological_process
GO:0001570VasculogenesisISSbiological_process
GO:0001656Metanephros developmentISSbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisISSbiological_process
GO:0001708Cell fate specificationISSbiological_process
GO:0001755Neural crest cell migrationISSbiological_process
GO:0001947Heart loopingISSbiological_process
GO:0001948Glycoprotein bindingIEAmolecular_function
GO:0002052Positive regulation of neuroblast proliferationIEAbiological_process
GO:0002076Osteoblast developmentIEAbiological_process
GO:0002320Lymphoid progenitor cell differentiationIMPbiological_process
GO:0003140Determination of left/right asymmetry in lateral mesodermISSbiological_process
GO:0004871Signal transducer activityIDAmolecular_function
GO:0005113Patched bindingIDAmolecular_function
GO:0005509Calcium ion bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005539Glycosaminoglycan bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005615Extracellular spaceIDA ISScellular_component
GO:0005634NucleusIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006897EndocytosisIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007224Smoothened signaling pathwayIEP ISSbiological_process
GO:0007228Positive regulation of hh target transcription factor activityISSbiological_process
GO:0007267Cell-cell signalingIEA ISSbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007389Pattern specification processISSbiological_process
GO:0007398Ectoderm developmentIEAbiological_process
GO:0007405Neuroblast proliferationISSbiological_process
GO:0007411Axon guidanceISSbiological_process
GO:0007417Central nervous system developmentISSbiological_process
GO:0007418Ventral midline developmentTASbiological_process
GO:0007442Hindgut morphogenesisIEAbiological_process
GO:0007507Heart developmentISSbiological_process
GO:0007596Blood coagulationIEAbiological_process
GO:0008209Androgen metabolic processISSbiological_process
GO:0008233Peptidase activityIEAmolecular_function
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0008284Positive regulation of cell proliferationIDA ISSbiological_process
GO:0009790Embryo developmentISSbiological_process
GO:0009880Embryonic pattern specificationTASbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0009953Dorsal/ventral pattern formationISSbiological_process
GO:0009986Cell surfaceISScellular_component
GO:0014003Oligodendrocyte developmentIEAbiological_process
GO:0014706Striated muscle tissue developmentIEAbiological_process
GO:0014858Positive regulation of skeletal muscle cell proliferationIEAbiological_process
GO:0014902Myotube differentiationIEAbiological_process
GO:0016015Morphogen activityNASmolecular_function
GO:0016539Intein-mediated protein splicingIEAbiological_process
GO:0021513Spinal cord dorsal/ventral patterningIEAbiological_process
GO:0021522Spinal cord motor neuron differentiationIEAbiological_process
GO:0021794Thalamus developmentIEAbiological_process
GO:0021904Dorsal/ventral neural tube patterningIEAbiological_process
GO:0021938Smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationIEAbiological_process
GO:0021978Telencephalon regionalizationIEAbiological_process
GO:0030010Establishment of cell polarityIEAbiological_process
GO:0030162Regulation of proteolysisISSbiological_process
GO:0030177Positive regulation of Wnt signaling pathwayIEAbiological_process
GO:0030324Lung developmentISSbiological_process
GO:0030326Embryonic limb morphogenesisISSbiological_process
GO:0030336Negative regulation of cell migrationISSbiological_process
GO:0030539Male genitalia developmentISSbiological_process
GO:0030850Prostate gland developmentISSbiological_process
GO:0030878Thyroid gland developmentIEAbiological_process
GO:0030900Forebrain developmentISSbiological_process
GO:0030901Midbrain developmentISSbiological_process
GO:0030902Hindbrain developmentISSbiological_process
GO:0031012Extracellular matrixIEAcellular_component
GO:0031016Pancreas developmentIEAbiological_process
GO:0031069Hair follicle morphogenesisIEAbiological_process
GO:0032435Negative regulation of proteasomal ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0033077T cell differentiation in thymusISSbiological_process
GO:0033089Positive regulation of T cell differentiation in thymusISSbiological_process
GO:0033092Positive regulation of immature T cell proliferation in thymusISSbiological_process
GO:0034244Negative regulation of transcription elongation from RNA polymerase II promoterIEAbiological_process
GO:0034504Protein localization to nucleusIEAbiological_process
GO:0035115Embryonic forelimb morphogenesisIEAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEAbiological_process
GO:0042127Regulation of cell proliferationISSbiological_process
GO:0042130Negative regulation of T cell proliferationIEAbiological_process
GO:0042307Positive regulation of protein import into nucleusIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0042481Regulation of odontogenesisISSbiological_process
GO:0042733Embryonic digit morphogenesisISSbiological_process
GO:0043010Camera-type eye developmentIEAbiological_process
GO:0043237Laminin-1 bindingISSmolecular_function
GO:0043369CD4-positive or CD8-positive, alpha-beta T cell lineage commitmentIDAbiological_process
GO:0045059Positive thymic T cell selectionISSbiological_process
GO:0045060Negative thymic T cell selectionISSbiological_process
GO:0045109Intermediate filament organizationIEAbiological_process
GO:0045121Membrane raftISScellular_component
GO:0045445Myoblast differentiationIEAbiological_process
GO:0045596Negative regulation of cell differentiationISSbiological_process
GO:0045880Positive regulation of smoothened signaling pathwayISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046638Positive regulation of alpha-beta T cell differentiationISSbiological_process
GO:0046639Negative regulation of alpha-beta T cell differentiationIEAbiological_process
GO:0048468Cell developmentISSbiological_process
GO:0048538Thymus developmentISSbiological_process
GO:0048557Embryonic digestive tract morphogenesisIEAbiological_process
GO:0048617Embryonic foregut morphogenesisIEAbiological_process
GO:0048643Positive regulation of skeletal muscle tissue developmentIEAbiological_process
GO:0048645Organ formationIEAbiological_process
GO:0048663Neuron fate commitmentISSbiological_process
GO:0048706Embryonic skeletal system developmentIEAbiological_process
GO:0048714Positive regulation of oligodendrocyte differentiationIEAbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeISSbiological_process
GO:0048839Inner ear developmentIEAbiological_process
GO:0048859Formation of anatomical boundaryIEAbiological_process
GO:0048864Stem cell developmentISSbiological_process
GO:0051155Positive regulation of striated muscle cell differentiationIEAbiological_process
GO:0051781Positive regulation of cell divisionIDAbiological_process
GO:0060020Bergmann glial cell differentiationIEAbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIEAbiological_process
GO:0060174Limb bud formationIEAbiological_process
GO:0060428Lung epithelium developmentIEAbiological_process
GO:0060439Trachea morphogenesisIEAbiological_process
GO:0060445Branching involved in salivary gland morphogenesisIEAbiological_process
GO:0060447Bud outgrowth involved in lung branchingIEAbiological_process
GO:0060458Right lung developmentIEAbiological_process
GO:0060459Left lung developmentIEAbiological_process
GO:0060463Lung lobe morphogenesisIEAbiological_process
GO:0060484Lung-associated mesenchyme developmentIEAbiological_process
GO:0060516Primary prostatic bud elongationIEAbiological_process
GO:0060523Prostate epithelial cord elongationIEAbiological_process
GO:0060662Salivary gland cavitationIEAbiological_process
GO:0060664Epithelial cell proliferation involved in salivary gland morphogenesisIEAbiological_process
GO:0060685Regulation of prostatic bud formationIEAbiological_process
GO:0060738Epithelial-mesenchymal signaling involved in prostate gland developmentIDAbiological_process
GO:0060769Positive regulation of epithelial cell proliferation involved in prostate gland developmentIEAbiological_process
GO:0060782Regulation of mesenchymal cell proliferation involved in prostate gland developmentIEAbiological_process
GO:0060783Mesenchymal smoothened signaling pathway involved in prostate gland developmentIEAbiological_process
GO:0060840Artery developmentIEAbiological_process
GO:0060916Mesenchymal cell proliferation involved in lung developmentIEAbiological_process
GO:0061053Somite developmentISSbiological_process
GO:0061189Positive regulation of sclerotome developmentIDAbiological_process
GO:0071285Cellular response to lithium ionIEAbiological_process
GO:0072001Renal system developmentIEPbiological_process
GO:0072136Metanephric mesenchymal cell proliferation involved in metanephros developmentISSbiological_process
GO:0080125Multicellular structure septum developmentIEAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:0090370Negative regulation of cholesterol effluxISSbiological_process
GO:1900175Regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetryNASbiological_process
GO:1900180Regulation of protein localization to nucleusIDAbiological_process
GO:2000062Negative regulation of ureter smooth muscle cell differentiationISSbiological_process
GO:2000063Positive regulation of ureter smooth muscle cell differentiationISSbiological_process
GO:2000357Negative regulation of kidney smooth muscle cell differentiationISSbiological_process
GO:2000358Positive regulation of kidney smooth muscle cell differentiationISSbiological_process
GO:2000729Positive regulation of mesenchymal cell proliferation involved in ureter developmentISSbiological_process
GO:2001054Negative regulation of mesenchymal cell apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12603031420.94883052700.72361770991.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0255927130
GSE13712_SHEARUp0.1728548808
GSE13712_STATICDown-0.0663234909
GSE19018Up0.0704400042
GSE19899_A1Up0.1406033454
GSE19899_A2Up0.3144366021
PubMed_21979375_A1Up0.2274564962
PubMed_21979375_A2Up0.0083389957
GSE35957Up0.1033421785
GSE36640Down-0.0130087069
GSE54402Up1.7224305412
GSE9593Down-0.1025683223
GSE43922Up0.0658896981
GSE24585Down-0.0813475782
GSE37065Down-0.1475628024
GSE28863_A1Down-0.0620866223
GSE28863_A2Up0.0703294844
GSE28863_A3Up0.4299463601
GSE28863_A4Up0.0225087394
GSE48662Up0.2163907898

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017061MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25798129Additionally, zonation and regeneration of the adrenal cortex are controlled by developmental signaling pathways, such as the sonic hedgehog, delta-like homolog 1, fibroblast growth factor, and WNT/beta-catenin pathways
25645196In sonic hedgehog (Shh)-driven MB, activation of Wnt signaling has been shown to suppress tumor growth by either beta-catenin-dependent or -independent inhibition of Shh signaling
22724383P53, p21, Wnt3a, Wnt5a, sonic hedgehog (Shh) mRNA was detected by Real time polymerase chain reaction (PCR) and Wnt5a protein was determined by Western blot
22641694Using a mouse model for medulloblastoma driven by chronic Sonic hedgehog (SHH) signaling, TERRA RNA was detected in tumor, but not adjacent normal cells using both RNA fluorescence in situ hybridization (FISH) and northern blotting
15136151Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis
15136151Lack of Sonic hedgehog (Shh) signaling, mediated by the Gli proteins, leads to severe pulmonary hypoplasia
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