HCSGD entry for ITSN1
1. General information
| Official gene symbol | ITSN1 |
|---|---|
| Entrez ID | 6453 |
| Gene full name | intersectin 1 (SH3 domain protein) |
| Other gene symbols | ITSN SH3D1A SH3P17 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005085 | Guanyl-nucleotide exchange factor activity | NAS | molecular_function |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005905 | Coated pit | IDA | cellular_component |
| GO:0007264 | Small GTPase mediated signal transduction | IEA TAS | biological_process |
| GO:0019209 | Kinase activator activity | IEA | molecular_function |
| GO:0030027 | Lamellipodium | IEA | cellular_component |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0030139 | Endocytic vesicle | IEA | cellular_component |
| GO:0032947 | Protein complex scaffold | IDA | molecular_function |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0043087 | Regulation of GTPase activity | NAS | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
| GO:0045202 | Synapse | IEA | cellular_component |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048488 | Synaptic vesicle endocytosis | TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0051897 | Positive regulation of protein kinase B signaling | IEA | biological_process |
| GO:0070064 | Proline-rich region binding | IPI | molecular_function |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9467532693 | 0.2328614034 | 0.9999902473 | 0.9298734759 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1624189688 |
| GSE13712_SHEAR | Up | 0.0163347207 |
| GSE13712_STATIC | Down | -0.0021175777 |
| GSE19018 | Up | 0.0695377008 |
| GSE19899_A1 | Down | -0.1981515999 |
| GSE19899_A2 | Down | -0.4424965618 |
| PubMed_21979375_A1 | Down | -0.1053202674 |
| PubMed_21979375_A2 | Down | -0.2066889463 |
| GSE35957 | Up | 0.3835318952 |
| GSE36640 | Down | -0.0481201270 |
| GSE54402 | Up | 0.0081667923 |
| GSE9593 | Up | 0.0042015322 |
| GSE43922 | Down | -0.4132257852 |
| GSE24585 | Up | 0.0078428958 |
| GSE37065 | Down | -0.1282343887 |
| GSE28863_A1 | Up | 0.1789323890 |
| GSE28863_A2 | Down | -0.0434636135 |
| GSE28863_A3 | Down | -0.1695429927 |
| GSE28863_A4 | Up | 0.0680336382 |
| GSE48662 | Down | -0.1714416371 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-296-3p | MIMAT0004679 | MIRT038428 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
