HCSGD entry for SGK1

1. General information

Official gene symbolSGK1
Entrez ID6446
Gene full nameserum/glucocorticoid regulated kinase 1
Other gene symbolsSGK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001558Regulation of cell growthTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0005246Calcium channel regulator activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0006814Sodium ion transportTASbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006950Response to stressTASbiological_process
GO:0006974Cellular response to DNA damage stimulusIEAbiological_process
GO:0007154Cell communicationIEAbiological_process
GO:0007616Long-term memoryTASbiological_process
GO:0008217Regulation of blood pressureTASbiological_process
GO:0015459Potassium channel regulator activityTASmolecular_function
GO:0017080Sodium channel regulator activityTASmolecular_function
GO:0017081Chloride channel regulator activityTASmolecular_function
GO:0030334Regulation of cell migrationTASbiological_process
GO:0032411Positive regulation of transporter activityTASbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0035091Phosphatidylinositol bindingIEAmolecular_function
GO:0042127Regulation of cell proliferationTASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0050790Regulation of catalytic activityTASbiological_process
GO:0051090Regulation of sequence-specific DNA binding transcription factor activityTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060453Regulation of gastric acid secretionTASbiological_process
GO:0070294Renal sodium ion absorptionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16020479090.01242543980.79411493410.2198358630

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.5468647796
GSE13712_SHEARUp0.8133124596
GSE13712_STATICUp0.8279468776
GSE19018Down-0.6125292418
GSE19899_A1Down-1.3629706783
GSE19899_A2Down-1.3577815164
PubMed_21979375_A1Down-0.3746245079
PubMed_21979375_A2Down-0.6663505317
GSE35957Up1.0176194382
GSE36640Down-0.0138597312
GSE54402Down-0.0703991014
GSE9593Down-0.3683272798
GSE43922Down-0.2817908852
GSE24585Up1.1174932116
GSE37065Up0.4282155644
GSE28863_A1Down-0.1482465710
GSE28863_A2Up0.6590937414
GSE28863_A3Down-0.1768000526
GSE28863_A4Down-0.1696336539
GSE48662Down-0.3676569221

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Riboflavin MonophosphateDB03247 EXPT01458
[4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acidDB07837 -
4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acidDB08191 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022117MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26230157Serum glucocorticoid-inducible kinase (SGK)1 belongs to a family of serine/threonine kinases regulated by various external stimuli
26230157SGK1 has been shown to be protective against reactive oxygen species (ROS) production and to be involved in processes regulating aging
26230157However, data on the direct relationship between SGK1 and senescence are sparse
26230157HUVECs over-expressing full-length SGK1 (wild-type SGK1 [SGK1WT]) showed a decrease in SA-beta-gal and p21 expression and a corresponding increase in hTERT activity in the early stages of aging
26230157The SGK1Delta60 isoform, lacking the amino-terminal 60 amino acids, did not show interaction with hTERT, suggesting a pivotal role of this protein site for the SGK1 anti-aging function
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