HCSGD entry for ZMAT3
1. General information
| Official gene symbol | ZMAT3 |
|---|---|
| Entrez ID | 64393 |
| Gene full name | zinc finger, matrin-type 3 |
| Other gene symbols | PAG608 WIG-1 WIG1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0040008 | Regulation of growth | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0055671251 | 0.9279909008 | 0.1966876510 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3244432648 |
| GSE13712_SHEAR | Down | -0.0666529101 |
| GSE13712_STATIC | Up | 0.1375418912 |
| GSE19018 | Up | 0.5984209659 |
| GSE19899_A1 | Up | 0.3665425211 |
| GSE19899_A2 | Up | 0.9066078025 |
| PubMed_21979375_A1 | Down | -0.1382779833 |
| PubMed_21979375_A2 | Up | 0.5992042327 |
| GSE35957 | Up | 1.2502654864 |
| GSE36640 | Up | 2.1078922517 |
| GSE54402 | Down | -0.3222019843 |
| GSE9593 | Up | 0.8870624482 |
| GSE43922 | Up | 0.0196875460 |
| GSE24585 | Up | 0.5341099275 |
| GSE37065 | Down | -0.0294679181 |
| GSE28863_A1 | Up | 0.1920889103 |
| GSE28863_A2 | Down | -0.1299453811 |
| GSE28863_A3 | Down | -0.6475888887 |
| GSE28863_A4 | Down | -0.1372171992 |
| GSE48662 | Up | 0.6077644531 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024666 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026966 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23085987 | Here, we demonstrate that Wig1 plays a critical role in this process through regulation of p21 mRNA stability |
| 23085987 | Wig1 controls the association of Argonaute2 (Ago2), a central component of the RNA-induced silencing complex (RISC), with target p21 mRNA via binding of the stem-loop structure near the microRNA (miRNA) target site |
| 23085987 | Wig1 plays an essential role in cell proliferation, as demonstrated in tumour xenografts in mice, and Wig1 and p21 mRNA levels are inversely correlated in human normal and cancer tissues |
| 23085987 | Together, our data indicate a novel role of Wig1 in RISC target accessibility, which is a key step in RNA-mediated gene silencing |
| 23085987 | In addition, these findings indicate that fine-tuning of p21 levels by Wig1 is essential for the prevention of cellular senescence |
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