HCSGD entry for NXN
1. General information
| Official gene symbol | NXN |
|---|---|
| Entrez ID | 64359 |
| Gene full name | nucleoredoxin |
| Other gene symbols | NRX TRG-4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004791 | Thioredoxin-disulfide reductase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0030178 | Negative regulation of Wnt signaling pathway | ISS | biological_process |
| GO:0031397 | Negative regulation of protein ubiquitination | ISS | biological_process |
| GO:0047134 | Protein-disulfide reductase activity | IEA | molecular_function |
| GO:0072358 | Cardiovascular system development | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8884642985 | 0.2036024087 | 0.9999902473 | 0.8737560320 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | Down | -0.6375735890 |
| GSE24585 | Up | 0.5146727715 |
| GSE37065 | Down | -0.7002641640 |
| GSE28863_A1 | Down | -0.1841253743 |
| GSE28863_A2 | Down | -0.5221024947 |
| GSE28863_A3 | Up | 0.1619679882 |
| GSE28863_A4 | Up | 0.0854844059 |
| GSE48662 | Up | 0.1321883855 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT001611 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022572 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023721 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039562 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045235 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049102 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
